Optimized protocol for the hepatic differentiation of induced pluripotent stem cells in a fluidic microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26970
Abstract: In the present study, we evaluated the performance of different protocols for the hepatic differentiation of human‐induced pluripotent stem cells (hiPSCs) in microfluidic biochips. Strategies for complete and partial on‐chip differentiation were tested. Unlike full… read more here.
Keywords: hepatic differentiation; differentiation; pluripotent stem; induced pluripotent ... See more keywords
Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.08.020
Abstract: Abstract Immortalized human hepatocytes (IHH) could provide an unlimited supply of hepatocytes, but insufficient differentiation and phenotypic instability restrict their clinical application. This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A)… read more here.
Keywords: ihh; liver function; hnf4a; hepatic differentiation ... See more keywords
Efficient hepatic differentiation of hydrogel microsphere-encapsulated human pluripotent stem cells for engineering prevascularized liver tissue
Sign Up to like & getrecommendations! Published in 2022 at "Biofabrication"
DOI: 10.1088/1758-5090/aca79b
Abstract: Liver tissue engineering is promising as an alternative strategy to treat liver failure. However, generating functional hepatocytes from stem cells is conventionally restricted by the immature status of differentiated cells. Besides, embedding hepatocytes in bulk… read more here.
Keywords: efficient hepatic; hepatic differentiation; hydrogel; liver tissue ... See more keywords
Freshwater Cyanotoxin Cylindrospermopsin Has Detrimental Stage-specific Effects on Hepatic Differentiation From Human Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2019 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy293
Abstract: Cylindrospermopsin (CYN) has been recognized as a potent waterborne hepatotoxin with an increasing environmental occurrence. However, CYN effects on the specific populations of hepatic cells involved in liver tissue development, renewal, and regeneration, have not… read more here.
Keywords: hepatic differentiation; stage specific; differentiation; embryonic stem ... See more keywords
Proliferation and survival of human amniotic epithelial cells during their hepatic differentiation
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191489
Abstract: Stem cells derived from placental tissues are an attractive source of cells for regenerative medicine. Amniotic epithelial cells isolated from human amnion (hAECs) have desirable and competitive characteristics that make them stand out between other… read more here.
Keywords: hepatic differentiation; haecs; proliferation; proliferation survival ... See more keywords
Hepatic Differentiation of Stem Cells in 2D and 3D Biomaterial Systems
Sign Up to like & getrecommendations! Published in 2020 at "Bioengineering"
DOI: 10.3390/bioengineering7020047
Abstract: A critical shortage of donor livers for treating end-stage liver failure signifies the urgent need for alternative treatment options. Hepatocyte-like cells (HLC) derived from various stem cells represent a promising cell source for hepatocyte transplantation,… read more here.
Keywords: hepatic differentiation; biomaterial systems; differentiation stem; stem ... See more keywords
Effects of Co-Culture Media on Hepatic Differentiation of hiPSC with or without HUVEC Co-Culture
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18081724
Abstract: The derivation of hepatocytes from human induced pluripotent stem cells (hiPSC) is of great interest for applications in pharmacological research. However, full maturation of hiPSC-derived hepatocytes has not yet been achieved in vitro. To improve… read more here.
Keywords: hepatic differentiation; hipsc; without huvec; culture ... See more keywords
Adipose-derived stem cells show hepatic differentiation potential and therapeutic effect in rats with acute liver failure
Sign Up to like & getrecommendations! Published in 2023 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2023072
Abstract: Hepatocyte transplantation contributes to the repair of liver damage, but hepatocyte resources are limited, making it difficult for this to become a routine treatment. Previous studies have confirmed that mesenchymal stem cells (MSCs) can be… read more here.
Keywords: stem; stem cells; liver failure; hepatic differentiation ... See more keywords
Overexpression of long noncoding RNA CUDR promotes hepatic differentiation of human umbilical cord mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10897
Abstract: Previous studies have shown that long noncoding RNAs (lncRNAs) are capable of regulating cell differentiation and pluripotency. The objective of the present study was to explore the effect of lncRNA cancer upregulated drug resistant (CUDR)… read more here.
Keywords: long noncoding; hepatic differentiation; overexpression; differentiation human ... See more keywords