Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes
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DOI: 10.1080/00498254.2022.2066581
Abstract: Abstract Despite the importance of mice as a preclinical species in drug testing, their hepatic and extrahepatic drug-metabolising characteristics are poorly understood. Here, we compared the P450-dependent drug oxidation activity in tissue microsomes and distribution… read more here.
Keywords: drug metabolising; liver intestine; hydroxylation; humans mice ... See more keywords
Risk of hepatic and extrahepatic cancer in NAFLD: A population‐based cohort study
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DOI: 10.1111/liv.15195
Abstract: Individuals with non‐alcoholic fatty liver disease (NAFLD) may be at greater risk of cancer. This study aimed to investigate the risk of hepatic and extrahepatic cancer compared to the general population in a population‐based cohort… read more here.
Keywords: risk hepatic; extrahepatic cancer; risk; hepatic extrahepatic ... See more keywords
The impacts of Elaeagnus umbellata Thunb. leaf and fruit aqueous extracts on mice hepatic, extrahepatic antioxidant and drug metabolizing enzymes related structures
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DOI: 10.1590/s2175-97902017000317095
Abstract: In this work, the potential chemopreventive activities of Elaeagnus umbellata fruit aqueous (EUFA) and leaf aqueous (EULA) extracts focusing on the modulatory influence of xenobiotic metabolizing enzymes (XMEs), antioxidant enzymes, glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase… read more here.
Keywords: elaeagnus umbellata; hepatic extrahepatic; fruit aqueous; metabolizing enzymes ... See more keywords
Hepatitis C: Problems to extinction and residual hepatic and extrahepatic lesions after sustained virological response
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DOI: 10.4254/wjh.v14.i1.62
Abstract: Loss of follow-up or reinfections hinder the expectations of hepatitis C eradication despite the existence of highly effective treatments. Moreover, the elimination of the infection does not imply the reversion of those chronic alterations derived… read more here.
Keywords: problems extinction; residual hepatic; hepatitis problems; extinction residual ... See more keywords