TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
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DOI: 10.1038/s41598-017-00671-1
Abstract: Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix. Moreover, TIMP-1 displays anti-apoptotic properties,… read more here.
Keywords: fibrogenesis carcinogenesis; fibrogenesis; hepatic fibrogenesis; timp ... See more keywords
JAM‐A is a multifaceted regulator in hepatic fibrogenesis, supporting LSEC integrity and stellate cell quiescence
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DOI: 10.1111/liv.15187
Abstract: Leukocyte infiltration is a hallmark of hepatic inflammation. The Junctional Adhesion Molecule A (JAM‐A) is a crucial regulator of leukocyte extravasation and is upregulated in human viral fibrosis. Reduced shear stress within hepatic sinusoids and… read more here.
Keywords: hepatic fibrogenesis; cell; jam multifaceted; jam ... See more keywords
Fibroblast Growth Factor 21 Reduces Cholesterol-Induced Hepatic Fibrogenesis by Inhibiting TGF-β/Smad3C Signaling Pathway in LX2 Cells
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DOI: 10.5812/hepatmon.113321
Abstract: Background: Liver fibrosis is often attributed to the activation of hepatic stellate cells (HSCs) and excessive scar formation in the liver. Advanced stages of the disease often lead to liver cirrhosis and hepatocellular carcinoma (HCC).… read more here.
Keywords: hepatic fibrogenesis; fibroblast growth; cholesterol; growth factor ... See more keywords