The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice: A Public Health Perspective
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DOI: 10.1002/hep.30207
Abstract: The recently published article by Hui et al. emphasizes the public health significance of diet-induced hepatic fibrosis; the research group elegantly highlighted the sophisticated and high-throughput genetic analysis of a "humanized" hyperlipidemic mouse model for progressive… read more here.
Keywords: fibrosis; diet induced; hepatic fibrosis; public health ... See more keywords
Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30227
Abstract: Normal liver sinusoidal endothelial cells (LSECs) promote quiescence of hepatic stellate cells (HSCs). Prior to fibrosis, LSECs undergo capillarization, which is permissive for HSC activation, the proximate event in hepatic fibrosis. The aims of this… read more here.
Keywords: progenitor cells; fibrosis; marrow endothelial; endothelial progenitor ... See more keywords
Hepatic fibrosis 2022: Unmet needs and a blueprint for the future
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DOI: 10.1002/hep.32285
Abstract: Steady progress over four decades toward understanding the pathogenesis and clinical consequences of hepatic fibrosis has led to the expectation of effective antifibrotic drugs, yet none has been approved. Thus, an assessment of the field… read more here.
Keywords: hepatic fibrosis; 2022 unmet; needs blueprint; fibrosis 2022 ... See more keywords
Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl‐2 in hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23097
Abstract: Hepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date. Hepatic stellate cells (HSCs) are the main cells involved in the formation… read more here.
Keywords: stellate cells; hepatic fibrosis; hepatic stellate; fibrosis ... See more keywords
Hesperetin derivative decreases CCl4‐induced hepatic fibrosis by Ptch1‐dependent mechanisms
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DOI: 10.1002/jbt.23149
Abstract: Hepatic fibrosis (HF), a continuous wound‐healing response of the liver to repeated injuries, is characterized by abnormal extracellular matrix (ECM) accumulation. Hepatic stellate cells (HSCs) are considered a major cell type for ECM production. However,… read more here.
Keywords: hepatic fibrosis; hesperetin derivative; medicine; ccl4 induced ... See more keywords
Myrrhone inhibits the progression of hepatic fibrosis by regulating the abnormal activation of hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23177
Abstract: We focus on exploring the antihepatic fibrosis effect of Myrrhone (Myr), a compound extracted from myrrh, and its effective target. Mouse hepatic stellate cells (HSCs) were cultured in vitro and activated by transforming growth factor‐β… read more here.
Keywords: stellate cells; hepatic fibrosis; myr; hepatic stellate ... See more keywords
Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30248
Abstract: Hepatic fibrosis can be considered as a deregulated wound healing process in response to chronic liver injury. Bone morphogenetic protein 13 (BMP13) has been described to promote bone and tendon repair. In this study, we… read more here.
Keywords: bmp13; expression; bone morphogenetic; fibrosis ... See more keywords
miR‐21‐regulated M2 polarization of macrophage is involved in arsenicosis‐induced hepatic fibrosis through the activation of hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30288
Abstract: Arsenicosis induced by chronic exposure to arsenic is recognized as one of the main damaging effects on public health. Exposure to arsenic can cause hepatic fibrosis, but the molecular mechanisms by which this occurs are… read more here.
Keywords: arsenicosis induced; fibrosis; polarization; hepatic fibrosis ... See more keywords
Bioengineered Multicellular Liver Microtissues for Modeling Advanced Hepatic Fibrosis Driven Through Non-Alcoholic Fatty Liver Disease.
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DOI: 10.1002/smll.202007425
Abstract: Despite considerable efforts in modeling liver disease in vitro, it remains difficult to recapitulate the pathogenesis of the advanced phases of non-alcoholic fatty liver disease (NAFLD) with inflammation and fibrosis. Here, a liver-on-a-chip platform with… read more here.
Keywords: fibrosis; non alcoholic; liver; hepatic fibrosis ... See more keywords
Ochratoxin a induces hepatic fibrosis through TGF‐β receptor I/Smad2/3 signaling pathway
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DOI: 10.1002/tox.23552
Abstract: Ochratoxin A (OTA) is a mycotoxin generated by Penicillium and Aspergillus species. It is often found in cereals. We hypothesized that OTA exposure induces epithelial–mesenchymal transition (EMT), leading to liver fibrosis. In this research, we… read more here.
Keywords: tgf receptor; hepatic fibrosis; smad2 signaling; tgf ... See more keywords
Autophagy affects hepatic fibrosis progression by regulating macrophage polarization and exosome secretion.
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DOI: 10.1002/tox.23795
Abstract: BACKGROUND In this study, the role of autophagy in hepatic fibrosis and its effects on macrophage polarization and exosomes (EVs) were verified by establishing hepatic fibrosis model and co-culture model, providing evidence for treatment. METHODS… read more here.
Keywords: macrophage polarization; fibrosis; fibrosis model; hepatic fibrosis ... See more keywords