Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase 1 Study
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1535
Abstract: TPN171 is a phosphodiesterase‐5 inhibitor. It is currently being developed in China to treat pulmonary arterial hypertension and erectile dysfunction (ED). This study aimed to compare the pharmacokinetics and safety of TPN171 across participants with… read more here.
Keywords: mild moderate; participants normal; tpn171; study ... See more keywords
Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics
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DOI: 10.1002/cpdd.847
Abstract: Cobimetinib is a kinase inhibitor indicated for use in combination with vemurafenib for treatment of unresectable/metastatic melanoma with specific BRAF mutations. Cobimetinib is extensively metabolized in liver; thus, patients with hepatic impairment (HI) might have… read more here.
Keywords: normal hepatic; hepatic impairment; hepatic function; drug ... See more keywords
Hepatic function imaging using dynamic Gd‐EOB‐DTPA enhanced MRI and pharmacokinetic modeling
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DOI: 10.1002/mrm.26520
Abstract: To determine whether pharmacokinetic modeling parameters with different output assumptions of dynamic contrast–enhanced MRI (DCE‐MRI) using Gd‐EOB‐DTPA correlate with serum‐based liver function tests, and compare the goodness of fit of the different output assumptions. read more here.
Keywords: pharmacokinetic modeling; hepatic function; enhanced mri; eob dtpa ... See more keywords
Single-Dose Pharmacokinetics of Milvexian in Participants with Mild or Moderate Hepatic Impairment Compared with Healthy Participants
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DOI: 10.1007/s40262-022-01110-9
Abstract: Patients with hepatic impairment receiving antithrombotic agents metabolized primarily through the liver can be at risk for bleeding. Milvexian (BMS-986177/JNJ-70033093) is a small-molecule, active-site inhibitor of activated Factor XI (FXIa). Modulation of FXI may provide… read more here.
Keywords: moderate hepatic; impairment; hepatic function; mild moderate ... See more keywords
Association of endocrine disrupting chemicals levels in serum, environmental risk factors, and hepatic function among 5- to 14-year-old children.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.153011
Abstract: Endocrine-disrupting chemicals (EDCs) might increase the risk of childhood diseases by disrupting hormone-mediated processes that are critical for growth and development during childhood, however, the association among the exposure level of EDCs such as Nonylphenol… read more here.
Keywords: risk; environmental risk; dmp; hepatic function ... See more keywords
Effect of Ritualistic Consumption of Ayahuasca on Hepatic Function in Chronic Users
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DOI: 10.1080/02791072.2018.1557355
Abstract: ABSTRACT Ayahuasca is a beverage obtained from decoctions of the liana Banisteriopsis caapi plus the shrub Psychotria viridis. This beverage contains a combination of monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) and N,N-dimethyltryptamine, the main… read more here.
Keywords: consumption; beverage; hepatic function; effect ritualistic ... See more keywords
Early Relative Change in Hepatic Function with Lenvatinib for Unresectable Hepatocellular Carcinoma
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DOI: 10.1159/000502095
Abstract: Background/Aim: Lenvatinib (LEN) has been developed for the treatment of unresectable hepatocellular carcinoma (u-HCC). We aimed to elucidate the relative change in hepatic reserve function early following LEN treatment in affected patients. Materials/Methods: From March… read more here.
Keywords: hepatocellular carcinoma; change hepatic; hepatic function; unresectable hepatocellular ... See more keywords
Hepatic function is associated with cognitive function in patients with stable schizophrenia
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DOI: 10.1186/s12888-025-07448-1
Abstract: The liver-brain axis, mediated by inflammatory cytokines, metabolic byproducts, and oxidative stress, shares pathological pathways with schizophrenia neurobiology. Despite this overlap, direct clinical evidence linking hepatic function indicators to psychiatric symptoms or cognitive function in… read more here.
Keywords: function indicators; stable schizophrenia; function; cognitive function ... See more keywords
Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice
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DOI: 10.1371/journal.pone.0335906
Abstract: The kynurenine pathway (KP) is the canonical route by which tryptophan is metabolised, almost all of which occurs in the liver, with significant expression of its enzymes also known in the kidney. We generated two… read more here.
Keywords: kynurenine pathway; acid; function preserved; renal hepatic ... See more keywords
Dietary and lifestyle oxidative balance scores and their impact on cardiovascular diseases: exploring the mediating influence of hepatic function and blood lipid levels
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DOI: 10.3389/fcvm.2025.1493271
Abstract: Background Limited evidence exists regarding the association between oxidative stress induced by dietary and lifestyle factors and cardiovascular diseases (CVDs). Methods We conducted a weighted analysis using data from 13,530 adults in the National Health… read more here.
Keywords: lipid levels; blood lipid; dietary lifestyle; cvds ... See more keywords
Efficacy and liver function preservation with donafenib combined with transarterial chemoembolization in unresectable hepatocellular carcinoma: An ALBI grade analysis
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DOI: 10.3389/fonc.2025.1612477
Abstract: Purpose This study evaluated the hepatoprotective effects and safety profile of donafenib combined with transarterial chemoembolization (TACE) in unresectable hepatocellular carcinoma (HCC) through analysis of albumin-bilirubin (ALBI) score modifications. Patients and methods We enrolled 36… read more here.
Keywords: function preservation; function; albi grade; efficacy ... See more keywords