Effects of Empagliflozin Treatment on Glycerol‐Derived Hepatic Gluconeogenesis in Adults with Obesity: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2020 at "Obesity"
DOI: 10.1002/oby.22854
Abstract: The aim of this study was to determine the effects of empagliflozin on glycerol‐derived hepatic gluconeogenesis in adults with obesity without type 2 diabetes mellitus (T2DM) using oral carbon 13 (13C)‐labeled glycerol. read more here.
Keywords: glycerol derived; derived hepatic; glycerol; hepatic gluconeogenesis ... See more keywords
Interleukin-13 ameliorates postischemic hepatic gluconeogenesis and hyperglycemia in rat model of stroke
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-020-00596-1
Abstract: Hyperglycemia is a well-known indicator of stroke prognosis, and one-third of nondiabetic patients develop postischemic hyperglycemia during the acute phase of stroke; this is related to relatively poor prognosis, high mortality, and impaired neurological recovery.… read more here.
Keywords: hepatic gluconeogenesis; rat model; postischemic hyperglycemia; hyperglycemia ... See more keywords
Roles of 14-3-3β and γ in regulation of the glucocorticoid receptor transcriptional activation and hepatic gluconeogenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.077
Abstract: The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that mediates the effects of glucocorticoids, and plays a crucial role in cell growth, development, inflammation, and gluconeogenesis. The 14-3-3 proteins bind to target proteins via… read more here.
Keywords: roles regulation; regulation glucocorticoid; hepatic gluconeogenesis; gluconeogenesis ... See more keywords
Acute fructose intake suppresses fasting-induced hepatic gluconeogenesis through the AKT-FoxO1 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2019.100638
Abstract: Excessive intake of fructose increases lipogenesis in the liver, leading to hepatic lipid accumulation and development of fatty liver disease. Metabolic alterations in the liver due to fructose intake have been reported in many studies,… read more here.
Keywords: fructose administration; hepatic gluconeogenesis; fasting induced; induced hepatic ... See more keywords
Thyroid stimulating hormone increases hepatic gluconeogenesis via CRTC2
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.02.015
Abstract: Epidemiological evidence indicates that thyroid stimulating hormone (TSH) is positively correlated with abnormal glucose levels. We previously reported that TSH has direct effects on gluconeogenesis. However, the underlying molecular mechanism remains unclear. In this study,… read more here.
Keywords: thyroid stimulating; increases hepatic; hepatic gluconeogenesis; crtc2 ... See more keywords
[13C]bicarbonate labelled from hyperpolarized [1-13C]pyruvate is an in vivo marker of hepatic gluconeogenesis in fasted state
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-021-02978-2
Abstract: Hyperpolarized [1- 13 C]pyruvate enables direct in vivo assessment of real-time liver enzymatic activities by 13 C magnetic resonance. However, the technique usually requires the injection of a highly supraphysiological dose of pyruvate. We herein… read more here.
Keywords: hyperpolarized 13c; pyruvate; hepatic gluconeogenesis; state ... See more keywords
Taraxasterol Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis via the PI3K/Akt Signaling Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Natural Product Communications"
DOI: 10.1177/1934578x231154068
Abstract: Objective: Taraxasterol (TS) is the main active compound of Taraxacum, which plays a significant role in the treatment of diabetes in many classic prescriptions. However, the mechanisms of TS in the treatment of diabetes remain… read more here.
Keywords: glycogen synthesis; pi3k akt; hepg2 cells; hepatic gluconeogenesis ... See more keywords
DMT efficiently inhibits hepatic gluconeogenesis by regulating the Gαq signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-17-0121
Abstract: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with complicated pathogenesis and targeting gluconeogenesis inhibition is a promising strategy for anti-diabetic drug discovery. G protein-coupled receptors (GPCRs) are classified as distinct families by… read more here.
Keywords: protein; regulating signaling; gluconeogenesis regulating; signaling pathway ... See more keywords
Recent advances of long non-coding RNAs in control of hepatic gluconeogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1167592
Abstract: Gluconeogenesis is the main process for endogenous glucose production during prolonged fasting, or certain pathological conditions, which occurs primarily in the liver. Hepatic gluconeogenesis is a biochemical process that is finely controlled by hormones such… read more here.
Keywords: hepatic gluconeogenesis; non coding; gluconeogenesis; advances long ... See more keywords
GADD45β Regulates Hepatic Gluconeogenesis via Modulating the Protein Stability of FoxO1
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9010050
Abstract: Increased hepatic gluconeogenesis is one of the main contributors to the development of type 2 diabetes. Recently, it has been reported that growth arrest and DNA damage-inducible 45 beta (GADD45β) is induced under both fasting… read more here.
Keywords: gadd45; stability foxo1; hepatic gluconeogenesis; protein stability ... See more keywords
The Role of Palmitoleic Acid in Regulating Hepatic Gluconeogenesis through SIRT3 in Obese Mice
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14071482
Abstract: Hepatic gluconeogenesis is a crucial process to maintain glucose level during starvation. However, unabated glucose production in diabetic patients is a major contributor to hyperglycemia. Palmitoleic acid is a monounsaturated fatty acid (16:1n7) that is… read more here.
Keywords: sirt3; role; palmitoleic acid; gluconeogenesis ... See more keywords