Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201910168
Abstract: Oral insulin therapy that targets the liver and further mimics glucose‐responsive secretion holds promise for correcting defects in glucose metabolism caused by peripheral delivery. This work describes the construction of polymersomes (Pep‐PMS), which are composed… read more here.
Keywords: pep pms; hepatic glucose; secretion; insulin ... See more keywords
IPMK modulates hepatic glucose production and insulin signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30827
Abstract: Hepatic glucose production (HGP) is crucial for the maintenance of normal glucose homeostasis. Although hepatic insulin resistance contributes to excessive glucose production, its mechanism is not well understood. Here, we show that inositol polyphosphate multikinase… read more here.
Keywords: ipmk; hepatic glucose; insulin signaling; glucose production ... See more keywords
Hepatic Glucose Metabolism and Its Disorders in Fish.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-85686-1_11
Abstract: Carbohydrate, which is the most abundant nutrient in plant-sourced feedstuffs, is an economically indispensable component in commercial compound feeds for fish. This nutrient can enhance the physical quality of diets and allow for pellet expansion… read more here.
Keywords: fish species; glucose metabolism; disorders fish; hepatic glucose ... See more keywords
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.10.034
Abstract: Summary Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which… read more here.
Keywords: glucagon; secretion; insulin secretion; blood glucose ... See more keywords
Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.09.024
Abstract: Summary Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear. Here, we demonstrate that leptin-induced depolarization of POMC neurons is associated with the augmentation of a voltage-gated… read more here.
Keywords: leptin; pomc; glucose production; pro opiomelanocortin ... See more keywords
Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.061
Abstract: Insulin action in the hypothalamus results in the suppression of hepatic glucose production (HGP). Obesity is often associated with a diminished response to insulin, leading to impaired suppression of HGP in obese mice. Here, we… read more here.
Keywords: insulin; obese mice; glucose production; mice ... See more keywords
Effects of prenatal nicotine exposure on hepatic glucose and lipid metabolism in offspring rats and its hereditability.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152378
Abstract: Prenatal nicotine exposure (PNE) could induce an increased susceptibility to multiple chronic diseases in adult offspring, that mainly caused by intrauterine maternal glucocorticoid (GC) over-exposure. We investigated the changes and inheritability of hepatic glucose and… read more here.
Keywords: prenatal nicotine; exposure; hepatic glucose; lipid metabolism ... See more keywords
Regulation of hepatic glucose metabolism in health and disease
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Endocrinology"
DOI: 10.1038/nrendo.2017.80
Abstract: The liver is crucial for the maintenance of normal glucose homeostasis — it produces glucose during fasting and stores glucose postprandially. However, these hepatic processes are dysregulated in type 1 and type 2 diabetes mellitus,… read more here.
Keywords: regulation hepatic; control hepatic; hepatic glucose; glucose metabolism ... See more keywords
Regulation of liver receptor homologue-1 by DDB2 E3 ligase activity is critical for hepatic glucose metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41411-x
Abstract: Liver receptor homologue-1 (LRH-1) plays a critical role in hepatic metabolism and disease. Here we show that LRH-1 protein stability is regulated by the cullin 4 (CUL4) E3 ubiquitin ligase complex. We found that DNA… read more here.
Keywords: receptor homologue; metabolism; liver receptor; glucose metabolism ... See more keywords
Let-7 underlies metformin-induced inhibition of hepatic glucose production
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122217119
Abstract: Significance A clear mechanistic understanding of metformin’s antidiabetic effects is lacking. This is because suprapharmacological concentrations of metformin have been used in most studies. Using mouse models and human primary hepatocytes, we show that metformin,… read more here.
Keywords: hepatic glucose; let; let underlies; glucose production ... See more keywords
Whole grains-derived functional ingredients against hyperglycemia: targeting hepatic glucose metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2023.2183382
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by the dysregulation of glucose homeostasis, resulting in hyperglycemia. However, concerns have been raised about the safety and efficacy of current hypoglycemic drugs due to undesirable side effects.… read more here.
Keywords: glucose metabolism; hepatic glucose; targeting hepatic; whole grains ... See more keywords