PAK4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32384
Abstract: BACKGROUND & AIMS p21 activated kinase 4 (PAK4), an oncogenic protein, has emerged as a promising target for anti-cancer drug development. Its role in oxidative stress conditions, however, remains elusive. We investigated the effects of… read more here.
Keywords: pak4; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Agmatine protects against sodium valproate–induced hepatic injury in mice via modulation of nuclear factor‐κB/inducible nitric oxide synthetase pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22227
Abstract: Valproate is a widely used drug against epilepsy and several other neurological disorders although it has deleterious hepatotoxic side effects. The current study was designed to test if agmatine as nitric oxide modulator has protective… read more here.
Keywords: valproate; nitric oxide; factor; hepatic injury ... See more keywords
Montelukast abrogates prednisolone‐induced hepatic injury in rats: Modulation of mitochondrial dysfunction, oxidative/nitrosative stress, and apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22231
Abstract: The aim of this study was to investigate the protective effect of montelukast (MTK) against prednisolone‐induced hepatic injury in rats. Twenty‐eight male albino rats were categorized into four equal groups. Group I served as the… read more here.
Keywords: oxidative nitrosative; prednisolone induced; induced hepatic; nitrosative stress ... See more keywords
miR-219a-5p Ameliorates Hepatic Ischemia/Reperfusion Injury via Impairing TP53BP2
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05535-4
Abstract: BackgroundHepatic ischemia/reperfusion (I/R) injury is a serious complication that occurs upon hypovolemic shock, liver resection, and transplantation. A significant age-dependent difference in the injury response to hepatic I/R in both human and animal models has… read more here.
Keywords: mir 219a; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Investigation of the molecular mechanisms of hepatic injury upon naphthalene exposure in zebrafish (Danio rerio)
Sign Up to like & getrecommendations! Published in 2018 at "Ecotoxicology"
DOI: 10.1007/s10646-018-1943-3
Abstract: Naphthalene has been used worldwide as a commercial insecticide for decades, which when detected in the environment can have various negative effects on non-target organism, such as hepatotoxicity. However, the molecular mechanisms of how naphthalene… read more here.
Keywords: hepatic injury; exposure; naphthalene exposure; zebrafish danio ... See more keywords
The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04173-7
Abstract: Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis (PF) and hepatotoxicity. This study aimed to investigate the influence of alpha lipoic… read more here.
Keywords: fibrosis; hepatic injury; pulmonary fibrosis; alpha lipoic ... See more keywords
Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05983-6
Abstract: Codeine (3-methylmorphine) is a known analgesic, antitussive, and antidiarrheal drug that is often abused for recreational purposes. It is metabolized in the liver via the cytochrome P450 system and thus hypothesized to induce hepatic injury… read more here.
Keywords: codeine; caspase; codeine induced; damage ... See more keywords
AMPK activation ameliorates fine particulate matter-induced hepatic injury
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08624-4
Abstract: Both the epidemiological and animal experimental studies have reported the association between PM 2.5 and respiratory, cardiovascular, and metabolic diseases. However, the study linking PM 2.5 and hepatic injury is few, and the relative mechanism… read more here.
Keywords: bat; ampk activation; induced hepatic; injury ... See more keywords
Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108894
Abstract: Accumulating evidence suggests that vitamin D (VD) has a therapeutic effect on non-alcoholic fatty liver disease (NAFLD). Pyroptosis and gut microbiota have been recognized as critical factors of the progression of NAFLD. However, the effect… read more here.
Keywords: pyroptosis; effect; high fat; gut microbiota ... See more keywords
Low-grade blunt hepatic injury and benefits of intensive care unit monitoring.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2017.09.003
Abstract: BACKGROUND We investigated low-grade, hemodynamically normal BHI associated with any of three interventions indicating ICU observation. METHODS BHI between 01/01/96-6/30/14 were reviewed. Two groups included: Group A (BHI grades 1-3) with normal initial systolic BP… read more here.
Keywords: grade; group; blunt hepatic; grade blunt ... See more keywords
Increase of SOX9 promotes hepatic ischemia/reperfusion (IR) injury by activating TGF-β1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.005
Abstract: Ischemia/reperfusion (IR) injury causes damage in aerobically metabolizing organs or tissues, which is an essential injury mechanism in various clinical settings. SRY-related high mobility group-Box gene 9 (SOX9) is a transcription factor of the SRY… read more here.
Keywords: apoptosis; sox9; ischemia reperfusion; reperfusion injury ... See more keywords