Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30097
Abstract: Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease (NAFLD) through simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid oxidation. However,… read more here.
Keywords: hepatic insulin; acetyl coa; inhibition; insulin resistance ... See more keywords
Resolving the Paradox of Hepatic Insulin Resistance
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.10.016
Abstract: Insulin resistance is associated with numerous metabolic disorders, such as obesity and type II diabetes, that currently plague our society. Although insulin normally promotes anabolic metabolism in the liver by increasing glucose consumption and lipid… read more here.
Keywords: insulin; hepatic insulin; paradox hepatic; insulin resistance ... See more keywords
Ethno-pharmacological insulin signaling induction of aqueous extract of Syzygium paniculatum fruits in a high-fat diet induced hepatic insulin resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113576
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The ethnopharmacological significance of the fruits of Syzygium paniculatum Gaertn (Magenta Cherry) is widely recognized in the Indian traditional medicine system to treat various disorders, such as diabetes, hyperlipidaemia, hypertension, and cardiovascular problems.… read more here.
Keywords: fat diet; insulin; hepatic insulin; high fat ... See more keywords
Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats
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DOI: 10.1016/j.lfs.2017.12.039
Abstract: Aim: Vitamin C and vitamin E supplementations and their beneficial effects on type 2 diabetes mellitus (T2DM) have been subjected to countless controversial data. Hence, our aim is to investigate the hepatic molecular mechanisms of… read more here.
Keywords: insulin; hepatic insulin; vitamin vitamin; supplementation ... See more keywords
Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2018.12.003
Abstract: CONTEXT Excessive adipose glucocorticoid action is associated with insulin resistance, but the mechanisms linking adipose glucocorticoid action to insulin resistance are still debated. We hypothesized that insulin resistance from excess glucocorticoid action may be attributed… read more here.
Keywords: adipose glucocorticoid; insulin; hepatic insulin; insulin resistance ... See more keywords
A mathematical model of the impact of insulin secretion dynamics on selective hepatic insulin resistance
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01627-9
Abstract: Physiological insulin secretion exhibits various temporal patterns, the dysregulation of which is involved in diabetes development. We analyzed the impact of first-phase and pulsatile insulin release on glucose and lipid control with various hepatic insulin… read more here.
Keywords: insulin; hepatic insulin; insulin secretion; model ... See more keywords
Molecular and Metabolic Markers of Fructose Induced Hepatic Insulin Resistance in Developing and Adult Rats are Distinct and Aegle marmelos is an Effective Modulator
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33503-x
Abstract: The time course of pathogenesis of fructose mediated hepatic insulin resistance (HepIR) is not well-delineated and we chronicle it here from post-weaning to adulthood stages. Weaned rats were provided for either 4 or 8 weeks,… read more here.
Keywords: insulin; hepatic insulin; molecular metabolic; insulin resistance ... See more keywords
The sodium–glucose cotransporter 2 inhibitor ipragliflozin improves liver function and insulin resistance in Japanese patients with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05704-y
Abstract: Sodium–glucose cotransporter 2 inhibitor (SGLT2i) treatment is a therapeutic approach for type 2 diabetes mellitus (T2DM). Some reports have shown that SGLT2i treatment improves insulin resistance; however, few studies have evaluated insulin resistance by the… read more here.
Keywords: insulin resistance; insulin; treatment; hepatic insulin ... See more keywords
Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2007856117
Abstract: Significance Hepatic insulin resistance is a chief pathogenic determinant in the development of type 2 diabetes, which is often associated with abnormal hepatic lipid regulation. Sphingolipids are a class of essential lipids in the liver,… read more here.
Keywords: insulin; hepatic insulin; glucose homeostasis; sphk2 ... See more keywords
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111737119
Abstract: Significance Hepatic insulin resistance is a well-recognized cause of hepatic glucose overproduction and fasting hyperglycemia in fatty liver disease and type-2 diabetes. Here, we have discovered that pharmacological inhibition of cullin neddylation by NAE1 inhibitor… read more here.
Keywords: cullin neddylation; cullin; insulin signaling; insulin ... See more keywords
Familial diabetes predisposes PCOS patients to insulin resistance (IR), reproductive impairment and hepatic dysfunction: effects of d-chiro inositol (DCI) and alpha lipoic acid (ALA) administration on hepatic insulin extraction (HIE) index
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2089107
Abstract: Abstract Objective PCOS is a syndrome is characterized by 2 out of 3 of the criteria established during the Rotterdam Consensus Conference. Recently the issue of insulin resistance (IR) has caught attention. Subjects A group… read more here.
Keywords: dci; hepatic insulin; ala administration; familial diabetes ... See more keywords