Characterization of Porcine Hepatic and Intestinal Drug Metabolizing CYP450: Comparison with Human Orthologues from A Quantitative, Activity and Selectivity Perspective
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-45212-0
Abstract: Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism. Porcine CYP450 has… read more here.
Keywords: drug metabolizing; cyp450; drug; porcine ... See more keywords
Gender Difference of Hepatic and Intestinal CYP3A4 in CYP3AHumanized Mice Generated by a Human Chromosome-engineering Technique.
Sign Up to like & getrecommendations! Published in 2017 at "Drug metabolism letters"
DOI: 10.2174/1872312811666170404153804
Abstract: BACKGROUND Cytochrome P450 3A4 (CYP3A4) is an important drug-metabolizing enzyme that is expressed in the liver and small intestine of humans. Various factors influence the expression of CYP3A4, but gender difference in CYP3A4 expression remains… read more here.
Keywords: cyp3a; gender difference; expression; cyp3a4 ... See more keywords