Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202204697
Abstract: Hepatic ischemia–reperfusion (IR) injury remains a common issue lacking effective strategy and validated pharmacological targets. Here, using an unbiased metabolomics screen, this study finds that following murine hepatic IR, liver 3‐hydroxyanthranilic acid (3‐HAA) and quinolinic… read more here.
Keywords: kynurenine pathway; reperfusion injury; exacerbates liver; hepatic ischemia ... See more keywords
TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32015
Abstract: Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes a large proportion of early graft failure and organ rejection cases. The identification of key regulators of hepatic I/R injury… read more here.
Keywords: interacting protein; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Effect of Hepatic Artery Spasm on a Rat Model of Hepatic Ischemia‐Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.14726
Abstract: To investigate hemodynamic changes in the hepatic artery after hepatic ischemia‐reperfusion injury (IRI) in rats via ultrasound (US) imaging and to discuss the protective effect of phentolamine (PHT) pretreatment on hepatic IRI. read more here.
Keywords: ischemia reperfusion; reperfusion injury; hepatic artery; hepatic ischemia ... See more keywords
Protective effect of pinocembrin from Penthorum chinense Pursh on hepatic ischemia reperfusion injury via regulating HMGB1/TLR4 signal pathway
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DOI: 10.1002/ptr.7605
Abstract: Hepatic ischemia–reperfusion injury (HIRI) is of common occurrence during liver surgery and transplantation. Pinocembrin (PIN) is a kind of flavonoid monomer extracted from the local traditional Chinese medicine Penthorum chinense Pursh (P. chinense). However, the… read more here.
Keywords: effect; hmgb1 tlr4; hepatic ischemia; chinense ... See more keywords
Hydroxychloroquine inhibiting neutrophil extracellular trap formation alleviates hepatic ischemia/reperfusion injury by blocking TLR9 in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108461
Abstract: Hepatic ischemia/reperfusion (I/R) injury may arise after partial hepatectomy and liver transplantation. Neutrophil extracellular traps (NETs) were involved in hepatic I/R injury. This study tested the hypothesis that blocking NETs formation could be a potential… read more here.
Keywords: blocking tlr9; hcq; formation; injury ... See more keywords
Pre-treatment with FK506 reduces hepatic ischemia-reperfusion injury in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2017.04.009
Abstract: AIM The study is aimed to investigate the protective effects and possible mechanism of tacrolimus (FK506) pre-treatment in hepatic ischemia-reperfusion injury in rats. METHODS The rats were randomly assigned into four groups, which were S,… read more here.
Keywords: treatment; reperfusion; fk506 pre; pre treatment ... See more keywords
Galectin-1 attenuates hepatic ischemia reperfusion injury in mice.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105997
Abstract: BACKGROUND Hepatic ischemia reperfusion injury (IRI) is a primary cause of organ dysfunction occurring during liver resection surgery and transplantation. Galectin-1, an endogenous lectin expressed on lymphoid organs, plays an important role in governing innate… read more here.
Keywords: galectin; reperfusion; mice; ischemia reperfusion ... See more keywords
Senkyunolide I attenuates hepatic ischemia/reperfusion injury in mice via anti-oxidative, anti-inflammatory and anti-apoptotic pathways.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107717
Abstract: BACKGROUND Senkyunolide I (SEI)exerts considerable protective effects in various disease models, but its effect on hepatic ischemia-reperfusion (I/R) injury remains unknown. This research aimed to investigate the effect of SEI in a murine model of… read more here.
Keywords: reperfusion; inflammatory; sei; mice ... See more keywords
Rimonabant ameliorates hepatic ischemia/reperfusion injury in rats: Involvement of autophagy via modulating ERK- and PI3K/AKT-mTOR pathways.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108140
Abstract: Hepatic ischemia/reperfusion (HIR), which can result in severe liver injury and dysfunction, is usually associated with autophagy and endocannabinoid system derangements. Whether or not the modulation of the autophagic response following HIR injury is involved… read more here.
Keywords: injury; akt mtor; hepatic ischemia; pi3k akt ... See more keywords
Hic-5 deficiency attenuates hepatic ischemia reperfusion injury through TLR4/NF-κB signaling pathways.
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DOI: 10.1016/j.lfs.2020.117517
Abstract: AIM To explore the role and mechanism of Hydrogen peroxide-inducible clone-5 (Hic-5) in hepatic ischemia reperfusion injury. METHODS Hic-5 KO and WT mice were used to establish the liver ischemia reperfusion model (HI/R). Primary hepatocytes… read more here.
Keywords: apoptosis; tlr4; ischemia reperfusion; injury ... See more keywords
Hyperoside Attenuates Hepatic Ischemia-Reperfusion Injury by Suppressing Oxidative Stress and Inhibiting Apoptosis in Rats.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.04.066
Abstract: PURPOSE Hepatic ischemia-reperfusion (IR) injury is a serious complication of many clinical conditions, which may lead to liver or multiple organ failure. Hyperoside, a flavonoid compound, has been reported to protect against myocardial and cerebral… read more here.
Keywords: reperfusion; ischemia reperfusion; reperfusion injury; injury ... See more keywords