Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.09.051
Abstract: Background Effective targeting therapies for common chronic liver disease nonalcoholic steatohepatitis (NASH) are in urgent need. MicroRNA-targeted therapeutics would be potentially an effective treatment strategy of hepatic diseases. Here we investigated the functional role of… read more here.
Keywords: hepatic mir; mir 221; steatohepatitis; 221 222 ... See more keywords
The Multiple Modulation of miR-122 in the Attenuation of Alcoholic Liver Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2018.02.036
Abstract: Dear Editors: I read with great interest for the article by Satishchandran et al. The authors have shown that the beneficial role of hepatic miR-122 in patients and mice with alcoholic liver disease (ALD) was… read more here.
Keywords: hepatic mir; ald; modulation; mir ... See more keywords
Hepatic miR-378 modulates serum cholesterol levels by regulating hepatic bile acid synthesis
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DOI: 10.7150/thno.53624
Abstract: Rationale: An improved understanding of thyroid hormone (TH) action on cholesterol metabolism will facilitate the identification of novel therapeutic targets for hypercholesterolemia. TH-regulated microRNAs (miRNAs) have been implicated in TH-controlled biological processes; however, whether and… read more here.
Keywords: hepatic mir; mir; mir 378; serum cholesterol ... See more keywords