Interaction effect between NAFLD severity and high carbohydrate diet on gut microbiome alteration and hepatic de novo lipogenesis
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DOI: 10.1080/19490976.2022.2078612
Abstract: ABSTRACT Nonalcoholic fatty liver disease (NAFLD) is associated with high carbohydrate (HC) intake. We investigated whether the relationship between carbohydrate intake and NAFLD is mediated by interactions between gut microbial modulation, impaired insulin response, and… read more here.
Keywords: gut microbiome; high carbohydrate; carbohydrate; hepatic novo ... See more keywords
Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis
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DOI: 10.1530/eje-21-0850
Abstract: Objective Metformin is a first-line pharmacotherapy in the treatment of type 2 diabetes, a condition closely associated with non-alcoholic fatty liver disease (NAFLD). Although metformin promotes weight loss and improves insulin sensitivity, its effect on… read more here.
Keywords: intrahepatic triglyceride; novo lipogenesis; treatment; increased hepatic ... See more keywords
Effects of Isocaloric Fructose Restriction on Ceramide Levels in Children with Obesity and Cardiometabolic Risk: Relation to Hepatic De Novo Lipogenesis and Insulin Sensitivity
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DOI: 10.3390/nu14071432
Abstract: Sugar intake, particularly fructose, is implicated as a factor contributing to insulin resistance via hepatic de novo lipogenesis (DNL). A nine-day fructose reduction trial, controlling for other dietary factors and weight, in children with obesity… read more here.
Keywords: insulin sensitivity; hepatic novo; novo lipogenesis; ceramide ... See more keywords