Generation of Hepatic Organoids with Biliary Structures.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8961-4_16
Abstract: Incorporation of bile drainage system into engineered liver tissue is an important issue to advance liver regenerative medicine. Our group reported that three-dimensional (3D) coculture of fetal liver cells (FLCs) and adult rat biliary epithelial… read more here.
Keywords: medicine; biliary structures; organoids biliary; generation hepatic ... See more keywords
A human multi-lineage hepatic organoid model for liver fibrosis.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26410-9
Abstract: To investigate the pathogenesis of a congenital form of hepatic fibrosis, human hepatic organoids were engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD). Here we show that these… read more here.
Keywords: anti fibrotic; fibrosis human; fibrosis; liver fibrosis ... See more keywords
A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cells and development"
DOI: 10.1089/scd.2017.0023
Abstract: The quest for physiologically active human hepatocyte-like cells for in vitro research and drug screening is high. The recent progress in the field of pluripotent stem cell (PSC)-derived hepatic cells within the last decade brings… read more here.
Keywords: derived hepatic; generation; hepatic organoids; stem ... See more keywords
Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11040493
Abstract: Simple Summary The elimination of reprogramming transgenes affects the differentiation potential of human induced pluripotent stem cells (hiPSCs) at the early embryonic development stage, but not during the late stage of development into hepatocytes and… read more here.
Keywords: induced pluripotent; differentiation; elimination reprogramming; reprogramming transgenes ... See more keywords