Hepatic PPARα is critical in the metabolic adaptation to sepsis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2018.12.037
Abstract: BACKGROUND & AIMS Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which… read more here.
Keywords: ppar; sepsis; ppara; hepatic ppar ... See more keywords
Is hepatic peroxisome proliferator‐activated receptor α essential for the metabolic effects of fibrates?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14126
Abstract: Peroxisome proliferator-activated receptor α (PPARα) is a member of the steroid/nuclear receptor superfamily and functions as a ligand-activated transcription factor. After ligand binding, PPARα forms a heterodimer with the retinoid X receptor, and the heterodimer… read more here.
Keywords: ppar; hepatic ppar; ppar activation; effects fibrates ... See more keywords
The loss of hepatic PPARα prompts fatty liver disease-induced hypertension and cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5723348
Abstract: Non-alcoholic fatty liver disease (NAFLD) often clusters with obesity, diabetes, and hyperlipidemia. For unknown reasons, the leading cause of death in patients with NAFLD is cardiovascular disease (CVD). Most preclinical models of NAFLD are induced… read more here.
Keywords: disease; hepatic ppar; physiology; mice ... See more keywords
Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis
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DOI: 10.15252/emmm.201911319
Abstract: Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease; however, recent advances support… read more here.
Keywords: ppar; sepsis; hepatic ppar; ppar function ... See more keywords
Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071667
Abstract: Pemafibrate (PEM) is a novel lipid-lowering drug classified as a selective peroxisome proliferator-activated receptor α (PPARα) modulator whose binding efficiency to PPARα is superior to that of fibrates. This agent is also useful for non-alcoholic… read more here.
Keywords: ppar; pem; relevant dose; clinically relevant ... See more keywords