TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300350
Abstract: The malignant transformation of hepatic progenitor cells (HPCs) in the inflammatory microenvironment is the root cause of hepatocarcinogenesis. However, the potential molecular mechanisms are still elusive. The HPCs subgroup is identified by single-cell RNA (scRNA)… read more here.
Keywords: hepatic progenitor; expression; transformation hepatic; progenitor cells ... See more keywords
FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2‐mediated glycolysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29759
Abstract: FoxA2 is an essential transcription factor for liver organogenesis and homeostasis. Although reduced expression of FoxA2 has been associated with chronic liver diseases, hepatic progenitor cells (HPCs) that are activated in these circumstances express FoxA2.… read more here.
Keywords: foxa2; glycolysis; pi3k akt; proliferation ... See more keywords
Tumor necrosis factor-α promotes hepatocellular carcinogenesis through the activation of hepatic progenitor cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.07.001
Abstract: Hepatocellular carcinoma (HCC) is an inflammation-related disease. Tumor necrosis factor alpha (TNF-α) is an important inflammatory factor and it has been confirmed to promote tumor growth and poor prognosis of HCC. Hepatic progenitor cells (HPCs)… read more here.
Keywords: progenitor cells; tumor necrosis; hepatic progenitor; activation ... See more keywords
Redox cell signaling and hepatic progenitor cells.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cell biology"
DOI: 10.1016/j.ejcb.2018.09.004
Abstract: Hepatic diseases are widespread in the world and organ transplantation is currently the only treatment for liver failure. New cell-based approaches have been considered, since stem cells may represent a possible source to treat liver… read more here.
Keywords: progenitor cells; liver diseases; hepatic progenitor; redox cell ... See more keywords
Blocking development of liver fibrosis augments hepatic progenitor cell‐derived liver regeneration in a mouse chronic liver injury model
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DOI: 10.1111/hepr.13351
Abstract: The roles of hepatic progenitor cells (HPCs) in regeneration of a diseased liver are unclear. Hepatic stellate cells (HSCs) contribute to liver fibrosis but are also a component of the HPC niche. Hepatic progenitor cells… read more here.
Keywords: liver regeneration; regeneration; hepatic progenitor; liver fibrosis ... See more keywords
Hepatic progenitor cells in metastatic liver carcinomas
Sign Up to like & getrecommendations! Published in 2018 at "Histopathology"
DOI: 10.1111/his.13450
Abstract: Hepatic progenitor cells (HPCs) are activated in various liver diseases, but their role in the carcinomatous environment remains unknown. We aimed to identify the possible presence and topography of HPCs in liver metastases. read more here.
Keywords: cells metastatic; progenitor cells; metastatic liver; liver carcinomas ... See more keywords
Immunohistochemical evaluation of the activation of hepatic progenitor cells and their niche in feline lymphocytic cholangitis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Feline Medicine and Surgery"
DOI: 10.1177/1098612x17699723
Abstract: Objectives The aim of the study was to compare the hepatic progenitor cell niche in healthy feline livers and the liver tissue of cats with lymphocytic cholangitis. Methods Immunohistochemical stainings for vimentin, laminin, beta (β)-catenin… read more here.
Keywords: liver tissue; cats lymphocytic; cholangitis; hepatic progenitor ... See more keywords
Mesenchymal Stem Cells (MSCs) in Targeted Drug Delivery: Literature Review and Exploratory Data on Migrating and Differentiation Capacities of Bone MSCs into Hepatic Progenitor Cells.
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DOI: 10.2174/1568026621666210708092728
Abstract: BACKGROUND AND OBJECTIVE Mesenchymal stem cells (MSCs), particularly bone MSCs (BMSCs) offer great potentials for targeted therapeutic applications due to their migratory and differentiation capacities. Significant advances have been achieved in the differentiation of hepatocyte… read more here.
Keywords: progenitor cells; differentiation; hepatic progenitor; stem cells ... See more keywords
Redox Control of the Immune Response in the Hepatic Progenitor Cell Niche
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00295
Abstract: The liver commonly self-regenerates by a proliferation of mature cell types. Nevertheless, in case of severe or protracted damage, the organ renewal is mediated by the hepatic progenitor cells (HPCs), adult progenitors capable of differentiating… read more here.
Keywords: regeneration; immune response; hepatic progenitor; niche ... See more keywords
Babao Dan decreases hepatocarcinogenesis by inhibiting hepatic progenitor cells malignant transformation via down-regulating toll-like receptor 4
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1073859
Abstract: Background Babao Dan (BBD) is a traditional Chinese medicine that has been widely used as a complementary and alternative medicine to treat chronic liver diseases. In this study, we aimed to observe the effect of… read more here.
Keywords: hepatic progenitor; babao dan; bbd; progenitor cells ... See more keywords
Syngeneic implantation of mouse hepatic progenitor cell-derived three-dimensional liver tissue with dense collagen fibrils
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i14.1444
Abstract: BACKGROUND Liver transplantation is a therapy for irreversible liver failure; however, at present, donor organs are in short supply. Cell transplantation therapy for liver failure is still at the developmental stage and is critically limited… read more here.
Keywords: cell; liver; hepatic progenitor; collagen fibrils ... See more keywords