Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease.
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DOI: 10.1016/j.stem.2021.04.010
Abstract: DNA base editors and prime editing technology enable therapeutic in situ correction of disease-causing alleles. These techniques could have broad applications for ex vivo editing of cells prior to transplantation in a range of diseases, but… read more here.
Keywords: derived hepatic; hepatic progenitors; disease; base ... See more keywords