Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications.
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DOI: 10.1016/j.scr.2018.06.004
Abstract: Liver organogenesis requires complex cell-cell interactions between hepatic endoderm cells and adjacent cell niches. Endothelial cells are key players for endoderm hepatic fate decision. We previously demonstrated that the endothelial cell niche promotes hepatic specification… read more here.
Keywords: stem cell; endothelial cells; endoderm cells; hepatic specification ... See more keywords