Gut–liver on a chip toward an in vitro model of hepatic steatosis
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26793
Abstract: Hepatic steatosis is a process of abnormal lipid deposition within the liver cells, often caused by excessive alcohol uptake or obesity. A conventional in vitro model for hepatic steatosis uses a liver cell culture, treated… read more here.
Keywords: liver chip; hepatic steatosis; model; gut liver ... See more keywords
Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32122
Abstract: BACKGROUND & AIMS Thioesterase superfamily member 2 (Them2) is highly expressed in liver and oxidative tissues, where it hydrolyzes long chain fatty acyl-CoA esters to free fatty acids and CoA. Although mice globally lacking Them2… read more here.
Keywords: skeletal muscle; hepatic steatosis; insulin; them2 ... See more keywords
Downregulation of glucose‐6‐phosphatase expression contributes to fluoxetine‐induced hepatic steatosis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4109
Abstract: Fluoxetine is a first‐line selective serotonin reuptake inhibitor widely applied for the treatment of depression; however, it induces abnormal hepatic lipid metabolism. Considering decreased expression or function of glucose‐6‐phosphatase (G6Pase), a key enzyme in gluconeogenesis,… read more here.
Keywords: hepatic steatosis; fatty acid; fluoxetine induced; expression ... See more keywords
Sclerostin aggravates insulin signaling in skeletal muscle and hepatic steatosis via upregulation of ER stress by mTOR‐mediated inhibition of autophagy under hyperlipidemic conditions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30873
Abstract: Recently, sclerostin (SCL), a circulating glycoprotein, was proposed to be a novel myokine involved in developing metabolic disorders. The association between SCL levels and insulin resistance in skeletal muscle, liver, and adipose tissue was studied… read more here.
Keywords: scl; skeletal muscle; hepatic steatosis; insulin ... See more keywords
Adipokine gremlin‐1 promotes hepatic steatosis via upregulation of ER stress by suppressing autophagy‐mediated signaling
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30982
Abstract: Gremlin‐1 (GR1) is a novel adipokine that is highly expressed in human adipocytes and has been shown to inhibit the BMP2/4‐TGFb signaling pathway. It has an effect on insulin sensitivity. Elevated levels of Gremlin have… read more here.
Keywords: stress; suppressing autophagy; stress suppressing; gr1 ... See more keywords
Hepatic steatosis after pediatric liver transplant
Sign Up to like & getrecommendations! Published in 2017 at "Liver Transplantation"
DOI: 10.1002/lt.24773
Abstract: Hepatic steatosis develops after liver transplantation (LT) in 30% of adults, and nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in nontransplanted children. However, posttransplant steatosis has been minimally studied in… read more here.
Keywords: hepatic steatosis; biopsy steatosis; transplant; liver ... See more keywords
Can negligible hepatic steatosis determined by magnetic resonance imaging–proton density fat fraction obviate the need for liver biopsy in potential liver donors?
Sign Up to like & getrecommendations! Published in 2018 at "Liver Transplantation"
DOI: 10.1002/lt.24965
Abstract: The purpose of this study is to determine whether magnetic resonance (MR)–proton density fat fraction (PDFF) estimate of negligible hepatic fat percentage ( read more here.
Keywords: hepatic steatosis; magnetic resonance; pdff; liver biopsy ... See more keywords
Heterogeneity of hepatic steatosis definitions and reporting of donor liver frozen sections among pathologists: A multicenter survey
Sign Up to like & getrecommendations! Published in 2022 at "Liver Transplantation"
DOI: 10.1002/lt.26466
Abstract: To the editor, The demand for donor livers continues to increase. Strategies to increase the donor liver pool include increasing donor registration, using living donors, and using “extended criteria” for donor livers. One such extended… read more here.
Keywords: steatosis; donor; hepatic steatosis; heterogeneity hepatic ... See more keywords
Associations between low‐carbohydrate and low‐fat diets and hepatic steatosis
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23551
Abstract: This study assessed the cross‐sectional associations of low‐carbohydrate diets (LCDs) and low‐fat diets (LFDs) with hepatic steatosis in the National Health and Nutrition Examination Survey. read more here.
Keywords: fat diets; associations low; low fat; hepatic steatosis ... See more keywords
Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real‐time two‐dimensional shear wave elastography: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6937
Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, while no drugs have been approved for its treatment. The pieces of evidence indicate that propolis as a novel anti‐inflammatory agent might be… read more here.
Keywords: liver disease; hepatic steatosis; steatosis fibrosis; steatosis ... See more keywords
Wheat germ improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo‐controlled, double‐blind clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7553
Abstract: Globally, Non‐alcoholic fatty liver disease (NAFLD) has a rising prevalence with no definitive pharmacological treatments. The aim of this study was to assess the clinical effects of wheat germ in patients with NAFLD. Fifty participants… read more here.
Keywords: group; wheat germ; placebo; hepatic steatosis ... See more keywords