Long-Term Culture of Mouse Fetal Hepatic Stem/Progenitor Cells.
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DOI: 10.1007/978-1-4939-8961-4_1
Abstract: Mouse fetal liver includes abundant hepatic stem/progenitor cells (HSPCs). Easy expansion with passage of HSPCs is necessary to obtain steady data. However, it is often difficult to enrich only HSPCs, and HSPCs can die when… read more here.
Keywords: progenitor cells; hepatic stem; mouse fetal; long term ... See more keywords
Vector-free in vivo trans-determination of adult hepatic stem cells to insulin-producing cells
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DOI: 10.1007/s11033-019-04870-z
Abstract: A reduction in the number of functional β-cells is the central pathological event in diabetes. Liver and ventral pancreas differentiates simultaneously in the same general domain of cells within embryonic endoderm. In addition, the precursor… read more here.
Keywords: vector free; hepatic stem; producing cells; stem ... See more keywords
Bone morphogenetic protein‐4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells
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DOI: 10.1111/hepr.12823
Abstract: Fetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic protein‐4 (BMP‐4) is essential for… read more here.
Keywords: fetal hepatic; proliferation terminal; terminal differentiation; hepatic stem ... See more keywords
Extensively expanded murine‐induced hepatic stem cells maintain high‐efficient hepatic differentiation potential for repopulation of injured livers
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DOI: 10.1111/liv.14509
Abstract: Shortage of donor hepatocytes limits hepatocyte transplantation for clinical application. Induced hepatic stem cells (iHepSCs) have capacities of self‐renewal and bipotential differentiations. Here, we investigated whether iHepSCs could be extensively expanded, and whether they could… read more here.
Keywords: hepatic stem; induced hepatic; stem cells; expanded murine ... See more keywords
Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma
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DOI: 10.3390/ijms23052801
Abstract: Cancer stemness evinces interest owing to the resulting malignancy and poor prognosis. We previously demonstrated that hepatic stem cell-like hepatocellular carcinoma (HpSC-HCC) is associated with high vascular invasion and poor prognosis. Dickkopf-1 (DKK-1), a Wnt… read more here.
Keywords: cell; stem cell; cell like; like hepatocellular ... See more keywords