Impaired Bile Secretion Promotes Hepatobiliary Injury in Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31239
Abstract: Hepatic crisis is an emergent complication affecting patients with sickle cell disease (SCD); however, the molecular mechanism of sickle cell hepatobiliary injury remains poorly understood. Using the knock‐in humanized mouse model of SCD and SCD… read more here.
Keywords: hepatobiliary injury; cell; cell disease; sickle cell ... See more keywords
Biliary bile acids in hepatobiliary injury - What is the link?
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DOI: 10.1016/j.jhep.2017.04.026
Abstract: The main trigger for liver injury in acquired cholestatic liver disease remains unclear. However, the accumulation of bile acids (BAs) undoubtedly plays a role. Recent progress in deciphering the pathomechanisms of inborn cholestatic liver diseases,… read more here.
Keywords: biliary bile; bile acids; injury link; acids hepatobiliary ... See more keywords
Clonorchis sinensis infection induces hepatobiliary injury via disturbing sphingolipid metabolism and activating sphingosine 1-phosphate receptor 2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1011378
Abstract: Clonorchis sinensis (C. sinensis) infection induces severe hepatobiliary injuries, which can cause inflammation, periductal fibrosis, and even cholangiocarcinoma. Sphingolipid metabolic pathways responsible for the generation of sphingosine-1-phosphate (S1P) and its receptor S1P receptors (S1PRs) have… read more here.
Keywords: hepatobiliary injury; infection; sinensis infection; sinensis ... See more keywords