Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis
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DOI: 10.1038/s41388-021-01749-x
Abstract: Cancer cells undergo metabolic adaption to sustain their survival and growth under metabolic stress conditions, yet the underlying mechanism remains largely unclear. It is also not known if lncRNAs contribute to this metabolic adaption of… read more here.
Keywords: synthesis pathway; hepatocellular carcinogenesis; cancer; serine synthesis ... See more keywords
Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6110-6
Abstract: BackgroundHepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic cell proliferation and survival. Key transcription… read more here.
Keywords: akt; loop; foxo3; hepatocellular carcinogenesis ... See more keywords
RLIM suppresses hepatocellular carcinogenesis by up-regulating p15 and p21
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20904
Abstract: Hepatocellular carcinogenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation and apoptosis. p15 and p21 are cyclin-dependent kinase inhibitors, which arrest cell proliferation and serve as critical tumor suppressors. Here… read more here.
Keywords: hepatocellular carcinogenesis; suppresses hepatocellular; rlim suppresses; p15 p21 ... See more keywords
Integrated analysis revealing the role of TET3-mediated MUC13 promoter hypomethylation in hepatocellular carcinogenesis.
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DOI: 10.2217/epi-2022-0395
Abstract: Aim: To explore the function and underlying mechanism of MUC13 in hepatocellular carcinoma (HCC) oncogenesis. Materials & Methods: Online databases and software were used to perform analyses of expression, methylation and enrichment pathway. Experiments were… read more here.
Keywords: promoter; muc13 promoter; promoter hypomethylation; tet3 ... See more keywords