Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105120
Abstract: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Serine‐arginine rich splicing factor 3 (SRSF3) plays a critical role in hepatocyte function and its loss in mice promotes chronic liver damage and leads to… read more here.
Keywords: hepatocellular carcinoma; damage; hepatocyte; dna damage ... See more keywords
Direct chemical induction of hepatocyte‐like cells with capacity for liver repopulation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32686
Abstract: Background and Aims: Cell fate can be directly reprogrammed from accessible cell types (e.g., fibroblasts) into functional cell types by exposure to small molecule stimuli. However, no chemical reprogramming method has been reported to date… read more here.
Keywords: chemical reprogramming; hepatocyte; hepatocyte like; like cells ... See more keywords
Inducing differentiation of human urine‐derived stem cells into hepatocyte‐like cells by coculturing with human hepatocyte L02 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29301
Abstract: To investigate the possibility of inducing differentiation of human urine‐derived stem cells (hUSCs) into hepatocyte‐like cells by coculturing with human hepatocyte L02 cells in vitro. read more here.
Keywords: human urine; inducing differentiation; differentiation human; derived stem ... See more keywords
Highlight report: spheroids from stem cell-derived hepatocyte-like cells
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2347-0
Abstract: In the August issue of the Archives of Toxicology Hassan Rashidi from the University of Edinburgh and colleagues published a study about 3D liver tissue-like spheroids generated from pluripotent stem cells (Rashidi et al. 2018).… read more here.
Keywords: hepatocyte like; rashidi 2018; like cells; stem cell ... See more keywords
HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.092
Abstract: The pancreas and liver are closely related developmentally and trans-differentiation of cells from one tissue into the cells of the other has been documented to occur after injury or exposure to selected growth factors or… read more here.
Keywords: cell; hepatocyte like; line; human pancreatic ... See more keywords
Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) signalling is involved in transdifferentiation of hepatocyte-like cells
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.280
Abstract: The identification of key regulators in hepatic progenitor cells differentiation is determinant for organ regeneration and may improve stem cell transplantation for end-stage liver disease. Mesenchymal, embryonic and pluripotent stem cells have been investigated as… read more here.
Keywords: transdifferentiation; heparg; differentiation; hepatocyte ... See more keywords
Hepatocyte nuclear factor 4A improves hepatic differentiation of immortalized adult human hepatocytes and improves liver function and survival
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.08.020
Abstract: Abstract Immortalized human hepatocytes (IHH) could provide an unlimited supply of hepatocytes, but insufficient differentiation and phenotypic instability restrict their clinical application. This study aimed to determine the role of hepatocyte nuclear factor 4A (HNF4A)… read more here.
Keywords: ihh; liver function; hnf4a; hepatic differentiation ... See more keywords
Rationally Designed Galactose Dendrimer for Hepatocyte-Specific Targeting and Intracellular Drug Delivery for the Treatment of Liver Disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c00649
Abstract: Over two million people die of liver disorders every year globally. Hepatocytes are the key cells affected in several acute and chronic liver diseases. The current clinical outcomes of liver-targeted nanoparticles are limited, necessitating the… read more here.
Keywords: drug delivery; hepatocyte; liver disorders;
Drug Design and Success of Prospective Mouse In Vitro-In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance (CLint).
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01001
Abstract: Hepatocyte intrinsic clearance (CLint) and methods of in vitro-in vivo extrapolation (IVIVE) are often used to predict plasma clearance (CLp) in drug discovery. While the prediction success of this approach is dependent on the chemotype,… read more here.
Keywords: clp; clearance; hepatocyte; success ... See more keywords
Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0170-z
Abstract: Human liver or hepatocyte transplantation is limited by a severe shortage of donor organs. Direct reprogramming of other adult cells into hepatic cells may offer a solution to this problem. In a previous study, we… read more here.
Keywords: human urine; like cells; transcription factor; hepatocyte ... See more keywords
Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16856-7
Abstract: Recently, it has been reported that human hepatocyte-like cells can be generated from fibroblasts by direct reprogramming technology. However, the conversion efficiency of human induced hepatocyte-like cells (hiHeps) is not high enough. In addition, comparative… read more here.
Keywords: hepatocyte like; like cells; prox1 foxa2; foxa2 foxa3 ... See more keywords