OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.028
Abstract: Inflammatory signaling pathways are tightly regulated to avoid chronic inflammation and the development of disease. OTULIN is a deubiquitinating enzyme that controls inflammation by cleaving linear ubiquitin chains generated by the linear ubiquitin chain assembly… read more here.
Keywords: hepatocellular carcinoma; kinase; inflammation; liver inflammation ... See more keywords
Molecular Mechanisms of Perfluorooctanoate-Induced Hepatocyte Apoptosis in Mice Using Proteomic Techniques.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental science & technology"
DOI: 10.1021/acs.est.7b02690
Abstract: The stability of perfluorooctanoate (PFOA) coupled with its wide use cause serious concerns regarding its potential risk to human health. The molecular mechanisms of PFOA-induced hepatotoxicity relevant to human health was investigated using both in… read more here.
Keywords: mechanisms perfluorooctanoate; pfoa; apoptosis; mice ... See more keywords
microRNA-199a-3p inhibits hepatic apoptosis and hepatocarcinogenesis by targeting PDCD4
Sign Up to like & getrecommendations! Published in 2020 at "Oncogenesis"
DOI: 10.1038/s41389-020-00282-y
Abstract: Hepatic apoptosis and the initiated liver inflammation play the initial roles in inflammation-induced hepatocarcinogenesis. Molecular mechanisms underlying the regulation of hepatocyte apoptosis and their roles in hepatocarcinogenesis have attracted much attention. A set of microRNAs… read more here.
Keywords: apoptosis; mir 199a; hepatic apoptosis; hepatocyte apoptosis ... See more keywords
Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration
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DOI: 10.1038/s41598-021-83082-7
Abstract: Hepatocellular carcinoma highly occurs in chronic hepatitis livers, where hepatocyte apoptosis is frequently detected. Apoptosis is a mechanism that eliminates mutated cells. Hepatocyte apoptosis induces compensatory liver regeneration, which is believed to contribute to tumor… read more here.
Keywords: apoptosis; liver regeneration; hepatocyte apoptosis; compensatory liver ... See more keywords
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2297268
Abstract: Objective Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly coexist and act synergistically to drive adverse clinical outcomes. This study is aimed at investigating the effects of exercise intervention and oral hypoglycaemic… read more here.
Keywords: ampk nrf2; stress; oxidative stress; hepatocyte apoptosis ... See more keywords
Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis
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DOI: 10.1371/journal.pone.0174913
Abstract: Background and aims Neutrophil infiltration of the liver is a typical feature of alcoholic liver injury. Human neutrophil peptide (HNP)-1 is an antimicrobial peptide secreted by neutrophils. The aim of this study was to determine… read more here.
Keywords: mice mice; apoptosis; hepatic fibrosis; hepatocyte apoptosis ... See more keywords
Ursodeoxycholic acid (UDCA) reduces hepatocyte apoptosis by inhibiting farnesoid X receptor (FXR) in hemorrhagic shock (HS).
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220525152811
Abstract: BACKGROUND Hemorrhagic shock (HS) is the most common cause of potentially preventable death after traumatic injury. Acute liver injury is an important manifestation of HS. Apoptosis plays an important role in liver injury. Farnesoid X… read more here.
Keywords: farnesoid receptor; apoptosis; group; receptor fxr ... See more keywords
Li-Dan-He-Ji Improves Infantile Cholestasis Hepatopathy Through Inhibiting Calcium-Sensing Receptor-Mediated Hepatocyte Apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00156
Abstract: Infantile cholestatic hepatopathy (ICH) is a clinical syndrome characterized by the accumulation of cytotoxic bile acids in infancy, leading to serious liver cirrhosis or liver failure. The aetiology of ICH is complicated and some of… read more here.
Keywords: apoptosis; hepatocyte apoptosis; sensing receptor; cholestasis ... See more keywords
LncRNA-Airn alleviates acute liver injury by inhibiting hepatocyte apoptosis via the NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022167
Abstract: Acute liver injury is a common and serious syndrome caused by multiple factors and unclear pathogenesis. If the injury persists, liver injury can lead to cirrhosis and liver failure and ultimately results in the development… read more here.
Keywords: injury inhibiting; liver injury; acute liver; injury ... See more keywords