Novel strategy to improve hepatocyte differentiation stability through synchronized behavior‐driven mechanical memory of iPSCs
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28285
Abstract: Cellular homeostasis is assumed to be regulated by the coordination of dynamic behaviors. Lack of efficient methods for synchronizing large quantities of cells makes studying cell culture strategies for bioprocess development challenging. Here, we demonstrate… read more here.
Keywords: hepatocyte differentiation; behavior driven; mechanical memory; differentiation ... See more keywords
Phenotypic diversity spanning the spectrum of hepatocyte differentiation impacts the outcome of patients with beta-catenin-mutated hepatocellular carcinomas.
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29500
Abstract: Denotes AASLD Presidential Poster of Distinction 225 Phenotypic diversity spanning the spectrum of hepatocyte differentiation impacts the outcome of patients with β-catenin-mutated hepatocellular carcinomas. Romain Desert1, Christelle Reynès2, Robert Sabatier2, Damien Grégoire3, Florian Rohart4,… read more here.
Keywords: differentiation impacts; spectrum hepatocyte; phenotypic diversity; spanning spectrum ... See more keywords
Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
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DOI: 10.1016/j.isci.2021.103235
Abstract: Summary Spheroid cultures of primary human hepatocytes (PHH) are used in studies of hepatic drug metabolism and toxicity. The cultures are maintained under different conditions, with possible confounding results. We performed an in-depth analysis of… read more here.
Keywords: conditions maintenance; differentiation function; maintenance hepatocyte; phh ... See more keywords
Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via sox9b Repression in Zebrafish
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DOI: 10.1155/2019/8451282
Abstract: Liver regeneration after most forms of injury is mediated through the proliferation of hepatocytes. However, when hepatocyte proliferation is impaired, such as during chronic liver disease, liver progenitor cells (LPCs) arising from the biliary epithelial… read more here.
Keywords: regeneration; notch; lpc hepatocyte; liver ... See more keywords
Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical Reports"
DOI: 10.3892/br.2022.1526
Abstract: Directed differentiation of human induced pluripotent stem cells (iPSCs) into hepatocytes could provide an unlimited source of liver cells, and therefore holds great promise for regenerative medicine, disease modeling, drug screening and toxicology studies. Various… read more here.
Keywords: hepatocyte differentiation; pluripotent stem; comparison; differentiation ... See more keywords