SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2018.11.054
Abstract: Silent information regulator 1 (SIRT1) is a type III histone deacetylase that is related to the inhibition of the inflammatory response. The aim of this study was to investigate the regulation of SIRT1 on isoniazid-induced… read more here.
Keywords: sirt1; induced hepatocyte; hepatocyte injury; isoniazid induced ... See more keywords
ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.865389
Abstract: Background: Though ASPP2 plays an important role in regulating cell apoptosis and autophagy in case of liver injury, there remains a lack of clarity on the molecular mechanism of ASPP2 regulating autophagy and apoptosis. Methods:… read more here.
Keywords: aspp2; apoptosis; autophagy apoptosis; mtorc1 ... See more keywords
Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v24.i9.992
Abstract: AIM To elucidate the potential role of autophagy and the protective effects of Jiang Zhi Granule (JZG) in metabolic stress-induced hepatocyte injury. METHODS An in vitro and in vivo approach was used in this study.… read more here.
Keywords: induced hepatocyte; jzg; stress induced; stress ... See more keywords