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   Articles with "hepatocyte like" as a keyword



MicroRNA‐Modified DNA Hexahedron‐Induced Hepatocyte‐Like Cells Integrating 3D Printed Scaffold for Acute Liver Failure Therapy

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recommendations! Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202402339

Abstract: Acute liver failure (ALF) involves extensive necrosis of liver cells and severe impairment of liver function. Hepatocyte transplantation holds promise for treating ALF by swiftly supporting liver functions and promoting liver regeneration. However, the scarcity… read more here.

Keywords: like cells; hepatocyte; hepatocyte like; acute liver ... See more keywords
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Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers

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recommendations! Published in 2018 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.26784

Abstract: Direct reprogramming represents an easy technique to generate induced hepatocytes (iHeps) from somatic cells. However, current protocols are accompanied by several drawbacks as iHeps are heterogenous and lack fully mature phenotypes of primary hepatocytes. Here,… read more here.

Keywords: hepatocyte like; like cells; repopulate decellularized; direct reprogramming ... See more keywords

Direct chemical induction of hepatocyte‐like cells with capacity for liver repopulation

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recommendations! Published in 2022 at "Hepatology"

DOI: 10.1002/hep.32686

Abstract: Background and Aims: Cell fate can be directly reprogrammed from accessible cell types (e.g., fibroblasts) into functional cell types by exposure to small molecule stimuli. However, no chemical reprogramming method has been reported to date… read more here.

Keywords: chemical reprogramming; hepatocyte; hepatocyte like; like cells ... See more keywords

Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte‐Like Cells Derived From Human‐Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip

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recommendations! Published in 2024 at "Journal of Applied Toxicology"

DOI: 10.1002/jat.4714

Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the main causes of critical liver diseases leading to steatosis, steatohepatitis, fibrosis, and ultimately to liver cirrhosis and hepatic carcinoma. In this study, the effect of palmitic… read more here.

Keywords: like cells; hepatocyte like; accumulation; palmitic acid ... See more keywords

Generation of insulin‐producing hepatocyte‐like cells from human Wharton's jelly mesenchymal stem cells as an alternative source of islet cells

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28352

Abstract: Islet cell transplantation, as a treatment of type 1 diabetes, has a lot of complexity such as allograft rejections and an insufficient number of donors. The liver can be used as a replacement for endogenous… read more here.

Keywords: insulin; hepatocyte like; like cells; stem cells ... See more keywords

Highlight report: spheroids from stem cell-derived hepatocyte-like cells

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recommendations! Published in 2018 at "Archives of Toxicology"

DOI: 10.1007/s00204-018-2347-0

Abstract: In the August issue of the Archives of Toxicology Hassan Rashidi from the University of Edinburgh and colleagues published a study about 3D liver tissue-like spheroids generated from pluripotent stem cells (Rashidi et al. 2018).… read more here.

Keywords: hepatocyte like; rashidi 2018; like cells; stem cell ... See more keywords

HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.07.092

Abstract: The pancreas and liver are closely related developmentally and trans-differentiation of cells from one tissue into the cells of the other has been documented to occur after injury or exposure to selected growth factors or… read more here.

Keywords: cell; hepatocyte like; line; human pancreatic ... See more keywords

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

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recommendations! Published in 2018 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2018.01.019

Abstract: Human iPS cell-derived hepatocyte-like cells are expected to be utilized in pharmaceutical research. However, the purity of high-functioning hepatocyte-like cells is not high enough. In particular, the purity of cytochrome P450 3A4 (CYP3A4), which is… read more here.

Keywords: hepatocyte like; like cells; human ips; ips cell ... See more keywords

Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.09.010

Abstract: Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications. However, the hepatic functions of iHep cells are… read more here.

Keywords: induced hepatocyte; hepatocyte like; cells activation; ihep ... See more keywords

A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.

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recommendations! Published in 2017 at "Cell stem cell"

DOI: 10.1016/j.stem.2017.01.011

Abstract: Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been hampered by the lack of models. However, cells with hepatocyte characteristics can be produced from induced pluripotent stem cells (iPSCs). Here, we have used hepatocyte-like… read more here.

Keywords: screen using; hepatocyte like; cardiac glycosides; like cells ... See more keywords

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-16856-7

Abstract: Recently, it has been reported that human hepatocyte-like cells can be generated from fibroblasts by direct reprogramming technology. However, the conversion efficiency of human induced hepatocyte-like cells (hiHeps) is not high enough. In addition, comparative… read more here.

Keywords: hepatocyte like; like cells; prox1 foxa2; foxa2 foxa3 ... See more keywords