Hepatocyte‐like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26784
Abstract: Direct reprogramming represents an easy technique to generate induced hepatocytes (iHeps) from somatic cells. However, current protocols are accompanied by several drawbacks as iHeps are heterogenous and lack fully mature phenotypes of primary hepatocytes. Here,… read more here.
Keywords: hepatocyte like; like cells; repopulate decellularized; direct reprogramming ... See more keywords
Direct chemical induction of hepatocyte‐like cells with capacity for liver repopulation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32686
Abstract: Background and Aims: Cell fate can be directly reprogrammed from accessible cell types (e.g., fibroblasts) into functional cell types by exposure to small molecule stimuli. However, no chemical reprogramming method has been reported to date… read more here.
Keywords: chemical reprogramming; hepatocyte; hepatocyte like; like cells ... See more keywords
Generation of insulin‐producing hepatocyte‐like cells from human Wharton's jelly mesenchymal stem cells as an alternative source of islet cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28352
Abstract: Islet cell transplantation, as a treatment of type 1 diabetes, has a lot of complexity such as allograft rejections and an insufficient number of donors. The liver can be used as a replacement for endogenous… read more here.
Keywords: insulin; hepatocyte like; like cells; stem cells ... See more keywords
Highlight report: spheroids from stem cell-derived hepatocyte-like cells
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2347-0
Abstract: In the August issue of the Archives of Toxicology Hassan Rashidi from the University of Edinburgh and colleagues published a study about 3D liver tissue-like spheroids generated from pluripotent stem cells (Rashidi et al. 2018).… read more here.
Keywords: hepatocyte like; rashidi 2018; like cells; stem cell ... See more keywords
HNF4alpha expression amplifies the glucocorticoid-induced conversion of a human pancreatic cell line to an hepatocyte-like cell.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.092
Abstract: The pancreas and liver are closely related developmentally and trans-differentiation of cells from one tissue into the cells of the other has been documented to occur after injury or exposure to selected growth factors or… read more here.
Keywords: cell; hepatocyte like; line; human pancreatic ... See more keywords
Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.01.019
Abstract: Human iPS cell-derived hepatocyte-like cells are expected to be utilized in pharmaceutical research. However, the purity of high-functioning hepatocyte-like cells is not high enough. In particular, the purity of cytochrome P450 3A4 (CYP3A4), which is… read more here.
Keywords: hepatocyte like; like cells; human ips; ips cell ... See more keywords
Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.010
Abstract: Recent progress in direct lineage reprogramming has enabled the generation of induced hepatocyte-like (iHep) cells and revealed their potential as an alternative to hepatocytes for medical applications. However, the hepatic functions of iHep cells are… read more here.
Keywords: induced hepatocyte; hepatocyte like; cells activation; ihep ... See more keywords
A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2017.01.011
Abstract: Efforts to identify pharmaceuticals to treat heritable metabolic liver diseases have been hampered by the lack of models. However, cells with hepatocyte characteristics can be produced from induced pluripotent stem cells (iPSCs). Here, we have used hepatocyte-like… read more here.
Keywords: screen using; hepatocyte like; cardiac glycosides; like cells ... See more keywords
Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16856-7
Abstract: Recently, it has been reported that human hepatocyte-like cells can be generated from fibroblasts by direct reprogramming technology. However, the conversion efficiency of human induced hepatocyte-like cells (hiHeps) is not high enough. In addition, comparative… read more here.
Keywords: hepatocyte like; like cells; prox1 foxa2; foxa2 foxa3 ... See more keywords
A proteomic time course through the differentiation of human induced pluripotent stem cells into hepatocyte-like cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39400-1
Abstract: Numerous in vitro models endeavour to mimic the characteristics of primary human hepatocytes for applications in regenerative medicine and pharmaceutical science. Mature hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (hiPSCs) are one such… read more here.
Keywords: hepatocyte like; human induced; like cells; time ... See more keywords
Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90708-3
Abstract: Ammonia has a cytotoxic effect and can therefore be used as a selection agent for enrichment of zone I hepatocytes. However, it has not yet been determined whether ammonia-treated hepatocyte-like cells are able to proliferate… read more here.
Keywords: propagation; enrichment; hepatocyte like; like cells ... See more keywords