Down‐regulation of hepatocyte nuclear factor‐4α and defective zonation in livers expressing mutant Z α1‐antitrypsin
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DOI: 10.1002/hep.29160
Abstract: α1‐Antitrypsin (AAT) deficiency is one of the most common genetic disorders and the liver disease due to the Z mutant of AAT (ATZ) is a prototype of conformational disorder due to protein misfolding with consequent… read more here.
Keywords: hepatocyte nuclear; nuclear factor; zonation livers; hepatology ... See more keywords
The molecular functions of hepatocyte nuclear factors - In and beyond the liver.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.11.026
Abstract: The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas and kidney. The spatial and temporal manner of HNF expression regulates… read more here.
Keywords: molecular functions; nuclear factors; beyond liver; functions hepatocyte ... See more keywords
Differentiation therapy with hepatocyte nuclear factor 4α for patients with hepatocellular carcinoma
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DOI: 10.1038/s41422-025-01142-3
Abstract: Dear Editor, Differentiation therapy is an approach designed to revert tumor cells to a normal cellular state, thereby adopting benign characteristics. 1 This approach has achieved hallmark success in treating acute promyelocytic leukemia (APL) but… read more here.
Keywords: differentiation; therapy; differentiation therapy; hepatocyte nuclear ... See more keywords
The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage
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DOI: 10.1038/s41467-021-27934-w
Abstract: The transcription factor hepatocyte nuclear factor 4 A (HNF4A) controls the metabolic features of several endodermal epithelia. Both HNF4A and HNF4G are redundant in the intestine and it remains unclear whether HNF4A alone controls intestinal lipid… read more here.
Keywords: factor hepatocyte; transcription factor; energy; hnf4a ... See more keywords
Role of Hepatocyte Nuclear Factor 4 Alpha in Liver Cancer
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DOI: 10.1055/a-2349-7236
Abstract: Abstract Liver cancer is the sixth most common cancer and the fourth leading cause of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and the incidence of HCC is on… read more here.
Keywords: cancer; hcc; hepatocyte nuclear; liver cancer ... See more keywords
A Hepatocyte Nuclear Factor BtabHNF4 Mediates Desiccation Tolerance and Fecundity in Whitefly (Bemisia tabaci)
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DOI: 10.1093/ee/nvac103
Abstract: Abstract Hepatocyte nuclear factor 4 (HNF4) is essential for glucose homeostasis and lipid metabolism in insects. However, little is known about the role of HNF4 in whiteflies. In the present study, we identified a hepatocyte… read more here.
Keywords: nuclear factor; hepatocyte nuclear; desiccation tolerance; btabhnf4 ... See more keywords
MODY5 Hepatocyte Nuclear Factor 1ß (HNF1ß)-Associated Nephropathy: experience from a regional monogenic diabetes referral centre in Singapore
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DOI: 10.1177/23247096211065626
Abstract: From our monogenic diabetes registry set-up at a secondary-care diabetes center, we identified a nontrivial subpopulation (~15%) of maturity-onset diabetes of the young (MODY) among people with young-onset diabetes. In this report, we describe the… read more here.
Keywords: hnf1b mody; mody; onset diabetes; hepatocyte nuclear ... See more keywords
Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells.
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DOI: 10.1681/asn.2016050508
Abstract: AKI is a frequent condition that involves renal microcirculation impairment, infiltration of inflammatory cells with local production of proinflammatory cytokines, and subsequent epithelial disorders and mitochondrial dysfunction. Peroxisome proliferator-activated receptor γ coactivator 1-α (PPARGC1A), a… read more here.
Keywords: respiration; hepatocyte nuclear; ppargc1a; factor ... See more keywords
Hepatocyte nuclear factor 4, alpha (HNF4A): A potential biomarker for chronic hypoxia in MCF7 breast cancer cell lines
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DOI: 10.18549/pharmpract.2025.3.3227
Abstract: Introduction: Hypoxia mediates cancer hallmarks and results from low oxygen levels due to irregularities in tumor vascularization or when the bulk of the tumor prevents oxygen diffusion and stimulates angiogenesis to compensate for low oxygen.… read more here.
Keywords: cancer; breast cancer; hepatocyte nuclear; hypoxia ... See more keywords
Hepatocyte Nuclear Factor 3β Plays a Suppressive Role in Colorectal Cancer Progression
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DOI: 10.3389/fonc.2019.01096
Abstract: Background and Objective: Hepatocyte nuclear factor 3β (HNF3β) is a key transcription factor in the development of the gastrointestinal tract. However, only few studies have examined its' expression, function and potential clinical significance in colorectal… read more here.
Keywords: progression; colorectal cancer; hepatocyte nuclear; expression ... See more keywords
The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis
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DOI: 10.3389/fonc.2022.1011230
Abstract: Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include… read more here.
Keywords: nuclear factor; factor; hepatocyte nuclear; role hepatocyte ... See more keywords