Imaging and Detection of Hepatocellular Carcinoma with a Hepatocyte-Specific Fluorescent Probe.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c05540
Abstract: Hepatocellular carcinoma is a highly invasive malignant tumor of the liver, which is the main cause of cancer-related death. The cancerization of hepatocytes may lead to the changes of cell microenvironment, active substances, and enzymes.… read more here.
Keywords: hepatocellular carcinoma; detection; carcinoma; specific fluorescent ... See more keywords
Hepatocyte-Specific SR-BI Gene Transfer Corrects Cardiac Dysfunction in Scarb1-Deficient Mice and Improves Pressure Overload-Induced Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.118.310946
Abstract: Objective— We investigated the hypothesis that HDL (high-density lipoprotein) dysfunction in Scarb1−/− mice negatively affects cardiac function both in the absence and in the presence of pressure overload. Second, we evaluated whether normalization of HDL… read more here.
Keywords: dysfunction; transfer; mice; hepatocyte specific ... See more keywords
Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.120687
Abstract: Liver damage is typically inferred from serum measurements of cytoplasmic liver enzymes. DNA molecules released from dying hepatocytes are an alternative biomarker, unexplored so far, potentially allowing for quantitative assessment of liver cell death. Here… read more here.
Keywords: dna; liver damage; cell free; liver ... See more keywords
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.90780
Abstract: Mechanisms of bile acid-induced (BA-induced) liver injury in cholestasis are controversial, limiting development of new therapies. We examined how BAs initiate liver injury using isolated liver cells from humans and mice and in-vivo mouse models.… read more here.
Keywords: liver injury; injury; hepatocyte specific; specific inflammatory ... See more keywords
Critical role for hepatocyte-specific eNOS in NAFLD and NASH.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db20-1228
Abstract: Regulation of endothelial nitric oxide synthase (eNOS) in hepatocytes may be an important target in nonalcoholic fatty liver disease (NAFLD) development and progression to steatohepatitis (NASH). In this study, we show genetic deletion and viral… read more here.
Keywords: role hepatocyte; nafld nash; hepatocyte specific; hepatocyte ... See more keywords
Hepatocyte-Specific Knock-Out of Nfib Aggravates Hepatocellular Tumorigenesis via Enhancing Urea Cycle
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.875324
Abstract: Nuclear Factor I B (NFIB) has been reported to promote tumor growth, metastasis, and liver regeneration, but its mechanism in liver cancer is not fully elucidated. The present study aims to reveal the role of… read more here.
Keywords: nfib; ass1 cps1; urea cycle; mice ... See more keywords
Hepatocyte-Specific Smad4 Deficiency Alleviates Liver Fibrosis via the p38/p65 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911696
Abstract: Liver fibrosis is a wound-healing response caused by the abnormal accumulation of extracellular matrix, which is produced by activated hepatic stellate cells (HSCs). Most studies have focused on the activated HSCs themselves in liver fibrosis,… read more here.
Keywords: liver fibrosis; specific smad4; fibrosis; hepatocyte specific ... See more keywords
Hepatocyte specific contrast enhanced MRI findings of focal nodular hyperplasia like nodules in liver following chemotherapy in pediatric cancer patients.
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic and interventional radiology"
DOI: 10.5152/dir.2019.19398
Abstract: PURPOSE We aimed to assess the MRI findings and follow-up of multiple focal nodular hyperplasia (FNH)- like lesions in pediatric cancer patients diagnosed by imaging findings. METHODS We retrospectively analyzed clinical data and MRI examinations… read more here.
Keywords: size; nodular hyperplasia; cancer; hepatocyte specific ... See more keywords