PDMS‐b‐PMOXA polymersomes for hepatocyte targeting and assessment of toxicity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.07.002
Abstract: Graphical abstract Figure. No Caption available. Abstract Nanoparticles, such as polymersomes, can be directed to the hepatic asialoglycoprotein receptor to achieve targeted drug delivery. In this study, we prepared asialofetuin conjugated polymersomes based on the… read more here.
Keywords: polymersomes hepatocyte; targeting assessment; toxicity; pdms pmoxa ... See more keywords
Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc05175e
Abstract: Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic… read more here.
Keywords: acid hepatocyte; glycyrrhetinic acid; unit anticancer; hepatocyte targeting ... See more keywords
A hepatocyte-targeting near-infrared ratiometric fluorescent probe for monitoring peroxynitrite during drug-induced hepatotoxicity and its remediation.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc07017f
Abstract: A novel hepatocyte-targeting near-infrared fluorescent probe named Gal-NIR is developed. Gal-NIR shows ratiometric response to ONOO- with high sensitivity and selectivity. Moreover, the probe can accurately target the hepatocyte, and thus is used for assessing… read more here.
Keywords: targeting near; fluorescent probe; induced hepatotoxicity; near infrared ... See more keywords
Preventing acute liver injury via hepatocyte-targeting nano-antioxidants.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13494
Abstract: Acute liver injury (ALI) is a severe liver disease that is characterized by sudden and massive hepatocyte necrosis and deterioration of liver functions. Oxidative stress is increasingly recognized as a key factor in the induction… read more here.
Keywords: hepatocyte; hepatocyte targeting; liver injury; acute liver ... See more keywords