Conversion of Fibroblasts to Hepatocytes In Vitro.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8961-4_9
Abstract: Primary hepatocytes are widely used in regenerative medicine, drug metabolism analysis, and in vitro drug screens. To overcome the shortage of liver donors, several strategies, such as differentiation of pluripotent stem cells and transdifferentiation from… read more here.
Keywords: conversion; fibroblasts hepatocytes; biology; hepatocytes vitro ... See more keywords
In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes
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DOI: 10.3390/biomedicines11030682
Abstract: Type II transmembrane serine proteases represent pharmacological targets for blocking entry and spread of influenza or coronaviruses. In this study, the depletion rates of the 3-amidinophenylalanine (3-APhA)-derived matriptase/TMPRSS2 inhibitors MI-463, MI-472, MI-485 or MI-1900 were… read more here.
Keywords: pharmacokinetic behavior; vitro pharmacokinetic; rat dog; dog monkey ... See more keywords