Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients
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DOI: 10.1002/hep.28697
Abstract: Although nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity, around 10%‐20% of nonobese Americans and Asians still develop NAFLD. Data on this special group are limited. We therefore studied the severity and clinical… read more here.
Keywords: nonobese patients; fatty liver; disease; nonalcoholic fatty ... See more keywords
Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis
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DOI: 10.1002/hep.28765
Abstract: Hepatocellular carcinoma (HCC) is a leading cause of morbidity and mortality in cirrhosis patients. This provides an opportunity to target the highest‐risk population, yet surveillance rates in the United States and Europe range from 10%… read more here.
Keywords: hepatocellular carcinoma; surveillance; cirrhosis; time ... See more keywords
Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease
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DOI: 10.1002/hep.28776
Abstract: Despite the high prevalence of nonalcoholic fatty liver disease (NAFLD), therapeutic options and noninvasive markers of disease activity and severity remain limited. We investigated the association between plasma biomarkers and liver histology in order to… read more here.
Keywords: plasma biomarkers; severity; liver disease; hepatology ... See more keywords
Hepatitis E in decompensated alcoholic cirrhosis
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DOI: 10.1002/hep.28792
Abstract: cholestasis. HEPATOLOGY 2016;64:535-548. 3) Marrone J, Lehmann GL, Soria LR, Pellegrino JM, Molinas S, Marinelli RA. Adenoviral transfer of human aquaporin-1 gene to rat liver improves bile flow in estrogen induced cholestasis. Gene Ther 2014;21:1058-1064.… read more here.
Keywords: physiol; water; aquaporin water; marinelli ... See more keywords
Liver injury from herbal and dietary supplements
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DOI: 10.1002/hep.28813
Abstract: Herbal and dietary supplements (HDS) are used increasingly both in the United States and worldwide, and HDS‐induced liver injury in the United States has increased proportionally. Current challenges in the diagnosis and management of HDS‐induced… read more here.
Keywords: dietary supplements; hds; herbal dietary; liver injury ... See more keywords
Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice ‡
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DOI: 10.1002/hep.28831
Abstract: Biliary‐committed progenitor cells (small mouse cholangiocytes; SMCCs) from small bile ducts are more resistant to hepatobiliary injury than large mouse cholangiocytes (LGCCs) from large bile ducts. The definitive endoderm marker, forkhead box A2 (FoxA2), is… read more here.
Keywords: cholestatic liver; senescence; liver; liver injury ... See more keywords
External validation of the nomogram for individualized prediction of hepatocellular carcinoma occurrence in patients with hepatitis C virus–related compensated cirrhosis
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DOI: 10.1002/hep.28865
Abstract: 1) Ajmera V, Perito ER, Bass NM, Terrault NA, Yates KP, Gill R, et al.; NASH Clinical Research Network. Novel plasma biomarkers associated with liver disease severity in adults with nonalcoholic fatty liver disease. HEPATOLOGY… read more here.
Keywords: fatty liver; external validation; validation nomogram; nonalcoholic fatty ... See more keywords
Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis
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DOI: 10.1002/hep.28887
Abstract: Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues and a negative correlation between PGK1 expression and… read more here.
Keywords: pgk1; cancer cell; cancer; liver cancer ... See more keywords
Anthony S. Tavill, M.D., F.A.C.P., F.R.C.P., F.A.C.G. (1936-2016).
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DOI: 10.1002/hep.28892
Abstract: Dr. Anthony (Tony) Tavill, a world-renowned physician and scientist in the field of hepatology, died peacefully on July 21, 2016, at his home in Shaker Heights, Ohio, surrounded by his loving family and friends. He… read more here.
Keywords: medicine; tavill; anthony tavill; tavill 1936 ... See more keywords
Polymorphisms in the IL‐1 gene cluster influence systemic inflammation in patients at risk for acute‐on‐chronic liver failure
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DOI: 10.1002/hep.28896
Abstract: Acute‐on‐chronic liver failure (ACLF) in cirrhosis is an increasingly recognized syndrome characterized by acute decompensation, organ failure(s) and high short‐term mortality. Recent findings suggest that an overexuberant systemic inflammation plays a primary role in ACLF… read more here.
Keywords: inflammation; gene cluster; aclf; failure ... See more keywords
Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis
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DOI: 10.1002/hep.28897
Abstract: Albumin is a potent scavenger of reactive oxygen species (ROS). However, modifications in albumin structure may reduce its antioxidant properties and modulate its immune‐regulatory functions. We examined alterations in circulating albumin in severe alcoholic hepatitis… read more here.
Keywords: severe alcoholic; stress; albumin; sah ... See more keywords