Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2214-z
Abstract: Bosentan is well known to induce cholestatic liver toxicity in humans. The present study was set up to characterize the hepatotoxic effects of this drug at the transcriptomic, proteomic, and metabolomic levels. For this purpose,… read more here.
Keywords: induced bosentan; hepatoma; omics based; human hepatoma ... See more keywords
Progression of conventional hepatic cell culture models to bioengineered HepG2 cells for evaluation of herbal bioactivities
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Letters"
DOI: 10.1007/s10529-018-2547-y
Abstract: Cancer cell lines of human tissue origin have been extensively used to investigate antiproliferative activity and toxicity of herbal extracts, isolated compounds, and anticancer drugs. These cell lines are genetically and/or epigenetically well characterized to… read more here.
Keywords: hepatoma; cell culture; hepg2 cells; culture models ... See more keywords
Three-dimensional culture of a genetically modified hepatoma cell line using macroporous gelatin beads
Sign Up to like & getrecommendations! Published in 2017 at "Cytotechnology"
DOI: 10.1007/s10616-017-0117-0
Abstract: Hepatoma cells are a candidate cell source for bio-artificial livers. However, they exhibit reduced liver functions compared with primary hepatocytes. In our previous study, genetically engineered mouse hepatoma cells were created by transduction with vectors… read more here.
Keywords: three dimensional; hepatoma; gelatin beads; macroporous gelatin ... See more keywords
Development of a genetically modified hepatoma cell line with heat-inducible high liver function
Sign Up to like & getrecommendations! Published in 2021 at "Cytotechnology"
DOI: 10.1007/s10616-021-00457-4
Abstract: Hepatoma cells are a promising cell source for the construction of bioartificial liver (BAL) systems owing to their high proliferative capability. However, their low liver function compared with primary hepatocytes is a major problem. In… read more here.
Keywords: hepatoma; cell line; liver; heat ... See more keywords
Tumor microenvironment-labile polymer-doxorubicin conjugate thermogel combined with docetaxel for in situ synergistic chemotherapy of hepatoma.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.07.021
Abstract: Topical chemotherapy with complementary drugs is one of the most promising strategies to achieve an effective antitumor activity. Herein, a synergistic strategy for hepatoma therapy by the combination of tumor microenvironment-sensitive polymer-doxorubicin (DOX) conjugate thermogel,… read more here.
Keywords: chemotherapy; hepatoma; thermogel; tumor microenvironment ... See more keywords
Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.042
Abstract: ABSTRACT Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently proved for clinical trials. We have previously reported, for the first time, NDV Anhinga strain has an efficient cancer… read more here.
Keywords: hepatoma; disease virus; candidate hepatoma; trail ... See more keywords
Aspirin inhibits the proliferation of hepatoma cells through controlling GLUT1-mediated glucose metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0014-x
Abstract: Aspirin can efficiently inhibit liver cancer growth, but the mechanism is poorly understood. In this study, we report that aspirin modulates glucose uptake through downregulating glucose transporter 1 (GLUT1), leading to the inhibition of hepatoma… read more here.
Keywords: hepatoma; hepatoma cells; controlling glut1; glucose metabolism ... See more keywords
A HCBP1 peptide conjugated ruthenium complex for targeted therapy of hepatoma.
Sign Up to like & getrecommendations! Published in 2020 at "Dalton transactions"
DOI: 10.1039/c9dt03856f
Abstract: An HCBP1 peptide-ruthenium conjugate (Ru-β-Ala-FQHPSFI) as a potential candidate for targeted therapy of hepatoma was synthesized. Ru-β-Ala-FQHPSFI shows drastically enhanced cytotoxicity and high selectivity for hepatoma cells versus noncancer liver cells. Raman imaging shows that… read more here.
Keywords: ruthenium; hepatoma; targeted therapy; therapy hepatoma ... See more keywords
Time Course Effect of R-Alpha-Lipoic Acid on Cellular Metabolomics in Cultured Hepatoma Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal food"
DOI: 10.1089/jmf.2016.3837
Abstract: Alpha-lipoic acid (LA) is a powerful antioxidant. LA has two enantiomers, R(+)-LA (R-LA) and S(-)-LA (S-LA). Of these, R-LA is naturally occurring and an essential cofactor in energy metabolism. R-LA treatment has been reported to… read more here.
Keywords: hepatoma; hepatoma cells; time course; alpha lipoic ... See more keywords
Role of miR-498 Combined with CREB1 in Apoptosis and Invasion of Hepatoma Cell Line
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/9621764
Abstract: Objective To detect the expression levels of miR-498 in the hepatoma cells and to clarify the biological roles of miR-498 in hepatoma by investigating CREB1, which is the target of miR-498. This study provides a… read more here.
Keywords: hepatoma cells; apoptosis; mir 498; hepatoma ... See more keywords
Hepatic Artery Embolization Induces the Local Overexpression of Transforming Growth Factor β1 in a Rat Hepatoma Model
Sign Up to like & getrecommendations! Published in 2019 at "Liver Cancer"
DOI: 10.1159/000502774
Abstract: Introduction: The underlying mechanism involved in the recurrence of hepatoma after hepatic arterial embolization (HAE) is not adequately examined. An immunosuppressive cytokine, transforming growth factor β1 (TGF-β1), can lead to tumor progression and is affected… read more here.
Keywords: hepatoma; rat hepatoma; group; tgf ... See more keywords