MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium
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DOI: 10.1002/advs.202203869
Abstract: Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and… read more here.
Keywords: mcu; cadmium; mitophagy; hepatotoxicity ... See more keywords
Immunomodulatory effect of Linalool (Lin) against CCl4‐induced hepatotoxicity and oxidative damage in rats
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DOI: 10.1002/bab.2371
Abstract: The current study explored the hepatoprotective and immunomodulatory effects of Linalool (Lin) against carbon tetrachloride (CCl4)‐induced toxicity in mice. Four study groups (n = 8 each) were used: (1) a negative control group and (2)… read more here.
Keywords: ccl4; linalool lin; group; hepatotoxicity ... See more keywords
Mannan‐binding lectin attenuates acetaminophen‐induced hepatotoxicity by regulating CYP2E1 expression via ROS‐dependent JNK/SP1 pathway
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DOI: 10.1002/eji.201847830
Abstract: Mannan‐binding lectin (MBL) acts as a soluble pattern recognition molecule in the innate immune system, which is primarily produced by the liver. MBL deficiency occurs with high frequency in the population and is reported to… read more here.
Keywords: binding lectin; induced hepatotoxicity; mbl; expression ... See more keywords
Does JNK Regulate Acetaminophen Hepatotoxicity by Modulating Nrf2-dependent Genes or Mitochondrial Oxidant Stress?
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DOI: 10.1002/hep.31442
Abstract: We read with interest the recent paper by Chen and coworkers who provided evidence for Nrf2 as a novel target for c-jun N-terminal kinase (JNK).1 Although we agree that JNK activation is a critical part… read more here.
Keywords: nrf2 dependent; jnk; regulate acetaminophen; hepatotoxicity ... See more keywords
Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity.
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DOI: 10.1002/hep.32270
Abstract: BACKGROUND AND AIMS Iron overload is a frequent finding in the general population. As the major iron storage site, liver is subject to iron toxicity. Farnesoid X receptor (FXR) regulates bile acid metabolism and is… read more here.
Keywords: iron; iron overload; mice; fxr ... See more keywords
Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4288
Abstract: As a serious infectious disease, tuberculosis threatens global public health. Isoniazid is the first‐line drug not only in active tuberculosis but also in its prevention. Severe hepatotoxicity greatly limits its use. Curcumin, extracted from turmeric,… read more here.
Keywords: sirt1 pgc; isoniazid induced; curcumin; hepatotoxicity ... See more keywords
Therapeutic potential of carfilzomib, an irreversible proteasome inhibitor, against acetaminophen‐induced hepatotoxicity in mice
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DOI: 10.1002/jbt.21877
Abstract: Overdose of acetaminophen (APAP) is often associated with hepatotoxicity. Carfilzomib (CFZ) shows multiple pharmacological activities including anti‐inflammatory potential. Therefore, this study was undertaken to evaluate the possible therapeutic effects of CFZ against APAP‐induced hepatotoxicity. Hepatotoxicity… read more here.
Keywords: induced hepatotoxicity; cfz post; hepatotoxicity; therapeutic potential ... See more keywords
Vitamin D3 and calcium cosupplementation alleviates cadmium hepatotoxicity in the rat: Enhanced antioxidative and anti‐inflammatory actions by remodeling cellular calcium pathways
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22440
Abstract: Although vitamin D (VD) and calcium (Ca) attenuate cadmium (Cd) metabolism, their combined antioxidant and anti‐inflammatory actions against Cd toxicity have not been previously explored. Hence, this study measured the protective effects of VD ± Ca supplements… read more here.
Keywords: anti inflammatory; inflammatory actions; vitamin calcium; group ... See more keywords
Hepatoprotective effect of arjunolic acid against cisplatin‐induced hepatotoxicity: Targeting oxidative stress, inflammation, and apoptosis
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DOI: 10.1002/jbt.22714
Abstract: Minimizing the adverse effects of chemotherapeutic agents remains a therapeutic challenge. Cisplatin (CP) induces hepatotoxicity through activation of oxidative stress, inflammation, and apoptosis cascades which is considered a significant drawback. Thus, this study aimed to… read more here.
Keywords: induced hepatotoxicity; group; hepatotoxicity; inflammation apoptosis ... See more keywords
The hepatoprotective effects of taurine against oxidative stress induced by isotretinoin in rats
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DOI: 10.1002/jbt.23178
Abstract: Liver disorders are one of the principal reasons for mortality in the world. Isotretinoin is a systemic retinoid that has been approved for therapy of acne vulgaris since 1982. This drug causes complications in the… read more here.
Keywords: induced isotretinoin; effects taurine; isotretinoin rats; hepatotoxicity ... See more keywords
Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride‐induced hepatotoxicity in rats
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DOI: 10.1002/jcb.28464
Abstract: It has been proposed carbon tetrachloride (CCl4) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has… read more here.
Keywords: induced hepatotoxicity; hepatoprotective effects; carbon tetrachloride; hepatotoxicity rats ... See more keywords