Cysteine-Based Protein Covalent Binding and Hepatotoxicity Induced by Emodin.
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DOI: 10.1021/acs.chemrestox.1c00358
Abstract: Emodin (EMD) is a major ingredient of Polygonum multiflorum Thunb. (PMT), which has shown adverse liver reactions. Despite multiple pharmacological activities, EMD is reported to show various toxicities. Our early study demonstrated the reactivity of… read more here.
Keywords: hepatotoxicity; covalent; hepatotoxicity induced; protein adduction ... See more keywords
Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish
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DOI: 10.1128/aac.01639-18
Abstract: Isoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment. ABSTRACT Isoniazid (INH) is… read more here.
Keywords: inflammatory state; hepatotoxicity induced; inh; apoptosis ... See more keywords
Targeting focal adhesion kinase to mitigate hepatotoxicity induced by PD-1 inhibition with or without KRAS G12C suppression.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e14597
Abstract: e14597 Background: Although PD-1 antibodies exhibit significant therapeutic potential, their clinical utility is often constrained by substantial liver toxicity. Recent advancements have highlighted the potent antitumor efficacy of targeting KRAS G12C in KRAS G12C-mutant cancers.… read more here.
Keywords: liver toxicity; kras g12c; inhibition; hepatotoxicity induced ... See more keywords
The incidence and risk factors of hepatotoxicity induced by perioperative hyperthermic intraperitoneal chemotherapy in gastrointestinal carcinoma patients: a retrospective study
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DOI: 10.2147/ott.s170398
Abstract: Aim To investigate the incidence and risk factors of hepatotoxicity induced by perioperative hyperthermic intraperitoneal chemotherapy (HIPEC) in gastrointestinal carcinoma patients. Patients and methods Patients with gastrointestinal cancers treated with surgery in the presence or… read more here.
Keywords: incidence; risk; surgery; hepatotoxicity induced ... See more keywords
Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A.
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DOI: 10.22092/ari.2022.357266.2005
Abstract: Bisphenol A (BPA) is a synthetic compound with alterations in the liver, antioxidant enzymes, and reproductive hormones. The therapeutic potential of Moringa oleifera extract has recently been considered. The present study aimed to estimate the… read more here.
Keywords: hepatotoxicity induced; moringa oleifera; oleifera; bisphenol ... See more keywords
Quercetin Effects on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Jundishapur Journal of Natural Pharmaceutical Products"
DOI: 10.5812/jjnpp.83523
Abstract: Background: Most nanoparticles have adverse impacts on the liver, which is a vital body organ, by the induction of oxidative stress. Objectives: This study was designed to evaluate the hepatoprotective effects of quercetin (QCT) against… read more here.
Keywords: nanoparticles rats; hepatotoxicity induced; titanium dioxide;