Pentosan Polysulfate to control hepcidin expression in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113867
Abstract: Hepcidin peptide is crucial in the regulation of systemic iron availability controlling its uptake from the diet and its release from the body storage tissues. Hepcidin dysregulation causes different human disorders ranging from iron overload… read more here.
Keywords: vitro vivo; control hepcidin; hepcidin; iron ... See more keywords
Anti-TNF-α Monoclonal Antibody Therapy Improves Anemia through Downregulating Hepatocyte Hepcidin Expression in Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2019 at "Mediators of Inflammation"
DOI: 10.1155/2019/4038619
Abstract: Anemia is one of the most common complications in patients with inflammatory bowel disease (IBD). Hepcidin as a key regulator of iron metabolism is pivotal in mediating the occurrence of anemia of chronic disease. Herein,… read more here.
Keywords: anemia; disease; hepcidin; ibd ... See more keywords
The Ectodomain of Matriptase-2 Plays an Important Non-Proteolytic Role in Suppressing Hepcidin Expression in Mice.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020005222
Abstract: Matriptase-2 (MT2), encoded by TMPRSS6, is a membrane-anchored serine protease, which plays a key role in suppressing hepatic hepcidin expression. MT2 is synthesized as a zymogen and undergoes autocleavage for activation. Previous studies suggest that… read more here.
Keywords: mt2; role suppressing; expression; non proteolytic ... See more keywords
Activation of STAT and SMAD Signaling Induces Hepcidin Re-Expression as a Therapeutic Target for β-Thalassemia Patients
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10010189
Abstract: Iron homeostasis is regulated by hepcidin, a hepatic hormone that controls dietary iron absorption and plasma iron concentration. Hepcidin binds to the only known iron export protein, ferroportin (FPN), which regulates its expression. The major… read more here.
Keywords: iron overload; iron; thalassemia patients; thalassemia ... See more keywords
Interrelations between Iron and Vitamin A—Studied Using Systems Approach
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031189
Abstract: A deficiency of vitamin A (VAD) and iron is the most common nutritional problem affecting people worldwide. Given the scale of the problem, the interactions between vitamin A and iron levels are widely studied. However,… read more here.
Keywords: systems approach; vitamin; using systems; expression ... See more keywords
Melatonin Regulates Iron Homeostasis by Inducing Hepcidin Expression in Hepatocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073593
Abstract: The pineal hormone, melatonin, plays important roles in circadian rhythms and energy metabolism. The hepatic peptide hormone, hepcidin, regulates iron homeostasis by triggering the degradation of ferroportin (FPN), the protein that transfers cellular iron to… read more here.
Keywords: expression; hepcidin expression; melatonin; iron homeostasis ... See more keywords
Glycochenodeoxycholate Affects Iron Homeostasis via Up-Regulating Hepcidin Expression
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14153176
Abstract: Increasing hepcidin expression is a vital factor in iron homeostasis imbalance among patients with chronic kidney disease (CKD). Recent studies have elucidated that abnormal serum steroid levels might cause the elevation of hepcidin. Glycochenodeoxycholate (GCDCA),… read more here.
Keywords: gcdca; hepcidin expression; iron homeostasis; hepcidin ... See more keywords