Activation of the mitogen‐activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13208
Abstract: The carbohydrate response element‐binding protein (ChREBP), a glucose‐responsive transcription factor that plays a critical role in the glucose‐mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isoforms: ChREBPα and ChREBPβ. However,… read more here.
Keywords: suppresses expression; expression chrebp; hepg2 cells; hepg2 ... See more keywords
Identification of the differential and synergic lipotoxic patterns of oleic acid, palmitic acid, and their mixture in 3D HepG2/C3A tissue using liver-on-chip technology.
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology progress"
DOI: 10.1002/btpr.70075
Abstract: The metabolic dysfunction-associated steatotic liver disease (MASLD, previously formerly known as non-alcoholic fatty liver disease, NAFLD) is rapidly expanding worldwide in parrallel with the obesity pandemic. Dietary fatty acids including oleic (OA) and palmitic acids… read more here.
Keywords: hepg2 c3a; chip technology; hepg2;
Investigating the effects of Ceylon cinnamon water extract on HepG2 cells for Type 2 diabetes therapy
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3778
Abstract: Cinnamon and its extracts have been used as herbal remedies for many ailments, including for reducing insulin resistance and diabetes complications. Type 2 diabetes mellitus (T2DM) is a rapidly growing health concern around the world.… read more here.
Keywords: cwe metformin; expression; gene expression; metformin ... See more keywords
Co‐cultured bone marrow mesenchymal stem cells repair thioacetamide‐induced hepatocyte damage
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11453
Abstract: Adult stem cells, such as bone marrow mesenchymal stem cells (BMSCs), are postdevelopmental cells found in many bone tissues. They are capable of multipotent differentiation and have low immune‐rejection characteristics. Hepatocytes may become inflamed and… read more here.
Keywords: hepg2; bone marrow; stem cells; damage ... See more keywords
Effect of HepG2 cell 3D cultivation on the metabolism of the anabolic androgenic steroid metandienone.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3455
Abstract: The elucidation of the metabolic fate of prohibited substances is crucial for the abuse detection. The human hepatocyte cell line HepG2 can be used to study biotransformation. In order to improve this in vitro model… read more here.
Keywords: cell; cultivation; biotransformation; anabolic androgenic ... See more keywords
Fusaric Acid Induces DNA Damage and Post‐Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2) Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26037
Abstract: Fusaric acid (FA), a common fungal contaminant of maize, is known to mediate toxicity in plants and animals; however, its mechanism of action is unclear. p53 is a tumor suppressor protein that is activated in… read more here.
Keywords: dna damage; post translational; translational modifications; hepg2 cells ... See more keywords
Imidazo[1,2‐a]Pyrazine Linked Benzimidazole, Tetrahydropyrimidine, and 1,3,4‐Oxadizoles as Anticancer Agents
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70114
Abstract: Diverse libraries of Imidazo[1,2‐a]pyrazine‐Benzimidazoles, Imidazo[1,2‐a]pyrazine‐tetrahydropyrimidine, and Imidazo[1,2‐a]pyrazine‐1,3,4‐Oxadiazoles were synthesized via simple and practical cyclocondensation protocols. Structures of target compounds were established by 1H and 13C NMR and mass spectral analysis. These newly synthesized compounds were… read more here.
Keywords: pyrazine linked; hepg2; imidazo pyrazine; tetrahydropyrimidine ... See more keywords
Effect of panaxytriol on cytochrome P450 3A4 via the pregnane X receptor regulatory pathway
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6290
Abstract: Panaxytriol (PXT) is one of the major effective components of red ginseng and Shenmai injection. The present study aimed to explore the effect of PXT on cytochrome P450 3A4 (CYP3A4) based on the pregnane X… read more here.
Keywords: regulatory pathway; cyp3a4; hepg2 cells; hepg2 ... See more keywords
Hypolipogenic effects of Icariside E4 via phosphorylation of AMPK and inhibition of MID1IP1 in HepG2 cells
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7584
Abstract: Though icariside E4 (IE4) is known to have anti‐noceptive, anti‐oxidant, anti‐Alzheimer and anti‐inflammatory effects, there was no evidence on the effect of IE4 on lipid metabolism so far. Hence, the hypolipogenic mechanism of IE4 was… read more here.
Keywords: mid1ip1; phosphorylation ampk; hepg2 cells; hepg2 ... See more keywords
Downregulation of estrogen receptor‐α36 expression attenuates metastasis of hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23469
Abstract: This study aimed to examine the role of estrogen receptor (ER)‐α36 in the metastasis of hepatocellular carcinoma (HCC) and in the epithelial‐mesenchymal transition (EMT). HCC HepG2 and Huh7 cells with the knocked‐down level of ER‐α36… read more here.
Keywords: cell; estrogen receptor; expression; huh7 ... See more keywords
Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2371-0
Abstract: Acetaminophen (APAP) is one of the most commonly used analgesics worldwide, and overdoses are associated with lactic acidosis, hepatocyte toxicity, and acute liver failure due to oxidative stress and mitochondrial dysfunction. Hepatoma cell lines typically… read more here.
Keywords: glycolysis; production; hepg2 cells; tca cycle ... See more keywords