Morin reduces inflammatory responses and alleviates lipid accumulation in hepatocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28578
Abstract: Morin (MO), a natural bioflavinoid, exists in many herbs. Previous studies have acclaimed MO's anti‐inflammatory, antidiabetic, antioxidant, antifibrotic, anticancer, and antihyperglycemic biological effects. This study aimed to assess the molecular mechanism of MO involved in… read more here.
Keywords: accumulation; lipid accumulation; tyloxapol induced; hepg2 cell ... See more keywords
Rapeseed peptide inhibits HepG2 cell proliferation by regulating the mitochondrial and P53 signaling pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12243
Abstract: BACKGROUND Rapeseed peptide, extracted from rapeseed protein, is known to have a variety of biological activities. In this study, the anti-proliferation effect and molecular mechanism of rapeseed peptide on HepG2 cells were investigated. RESULTS In… read more here.
Keywords: proliferation; rapeseed peptide; hepg2 cell; p53 ... See more keywords
Evaluation of cytotoxicity of nanolipid carriers with structured Buriti oil in the Caco-2 and HepG2 cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-020-02308-6
Abstract: Buriti oil is rich in monounsaturated fatty acids, carotenoids and tocopherols and it is used for the treatment of various diseases. One strategy to restructure the triglycerides is enzymatic interesterification and nanocarriers have been employed… read more here.
Keywords: buriti oil; cell lines; caco hepg2; hepg2 cell ... See more keywords
Identification and characterization of tilapia antioxidant peptides that protect AAPH-induced HepG2 cell oxidative stress
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2021.104662
Abstract: Abstract Nine novel peptides from tilapia hydrolysate were isolated and identified to be EKL, EKP, HKPA, ELSC, ALSC, ASLCH, SLCH, LPGYF, and LEVPGY. In addition, six fragments from in silico gastrointestinal digestion of the identified… read more here.
Keywords: hepg2 cell; aaph induced; induced hepg2; oxidative stress ... See more keywords
Hyperglycaemia‐induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS‐mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein
Sign Up to like & getrecommendations! Published in 2021 at "Diabetic Medicine"
DOI: 10.1111/dme.14713
Abstract: Diabetic population have a twofold to threefold increased risk of developing liver cancer, and hyperglycaemia is a prime causative factor that propends the tumour cells to undergo aggressive metabolic growth. In this study, we aimed… read more here.
Keywords: cell proliferation; induced human; hyperglycaemia induced; hepg2 cell ... See more keywords
Cucurbitacin I exhibits anticancer efficacy through induction of apoptosis and modulation of JAK/STAT3, MAPK/ERK, and AKT/mTOR signaling pathways in HepG2 cell line.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.14333
Abstract: Hepatocellular carcinoma is a common cancer type, especially among men. Although cucurbitacin I (CuI), widely found in plants belonging to the Ecballium elaterium (E. L) plant family, has been shown to have antitumorigenic properties in… read more here.
Keywords: apoptosis; cui; hepg2 cell; akt mtor ... See more keywords
Phyto-Mediated Synthesis of Porous Titanium Dioxide Nanoparticles From Withania somnifera Root Extract: Broad-Spectrum Attenuation of Biofilm and Cytotoxic Properties Against HepG2 Cell Lines
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.01680
Abstract: There is grave necessity to counter the menace of drug-resistant biofilms of pathogens using nanomaterials. Moreover, we need to produce nanoparticles (NPs) using inexpensive clean biological approaches that demonstrate broad-spectrum inhibition of microbial biofilms and… read more here.
Keywords: tio2; cell lines; tio2 nps; biofilm ... See more keywords
Chenodeoxycholic Acid Enhances the Effect of Sorafenib in Inhibiting HepG2 Cell Growth Through EGFR/Stat3 Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.836333
Abstract: Background Hepatocellular carcinoma (HCC) is a highly invasive disease with a high mortality rate. Our previous study found that Chenodeoxycholic acid (CDCA) as an endogenous metabolite can enhance the anti-tumor effect. Sorafenib has limited overall… read more here.
Keywords: effect; effect sorafenib; cell growth; hepg2 cell ... See more keywords
Naringenin Induces HepG2 Cell Apoptosis via ROS-Mediated JAK-2/STAT-3 Signaling Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28114506
Abstract: Hepatocarcinoma is one of the most prevalent digestive system tumors worldwide and lacks effective therapy. Recently, naringenin has been isolated from some citrus fruits, and its anticancer effects have been tested. However, the molecular mechanisms… read more here.
Keywords: cell; apoptosis; hepg2 cell; cell apoptosis ... See more keywords
Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020211
Abstract: Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (1). Target compounds 7a–f were produced… read more here.
Keywords: molecular docking; cell line; anti cancer; hepg2 cell ... See more keywords