Upstream stimulating factor 1 suppresses autophagy and hepatic lipid droplet catabolism by activating mTOR
Sign Up to like & getrecommendations! Published in 2018 at "Febs Letters"
DOI: 10.1002/1873-3468.13203
Abstract: Previous studies indicate that the transcription factor upstream stimulating factor 1 (USF1) is involved in the regulation of lipid and glucose metabolism. However, the role of USF1 in lipid‐induced autophagy remains unknown. Interestingly, we found… read more here.
Keywords: suppresses autophagy; stimulating factor; upstream stimulating; mtor ... See more keywords
Suppressed de novo lipogenesis by plasma membrane citrate transporter inhibitor promotes apoptosis in HepG2 cells
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DOI: 10.1002/2211-5463.12435
Abstract: Suppression of the expression or activities of enzymes that are involved in the synthesis of de novo lipogenesis (DNL) in cancer cells triggers cell death via apoptosis. The plasma membrane citrate transporter (PMCT) is the… read more here.
Keywords: citrate; apoptosis; hepg2 cells; pmcti ... See more keywords
Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment
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DOI: 10.1002/2211-5463.12628
Abstract: Increased glucose consumption is a known hallmark of cancer cells. Increased glycolysis provides ATP, reducing agents and substrates for macromolecular synthesis in intensely dividing cells. Therefore, inhibition of glycolysis is one strategy in anticancer therapy… read more here.
Keywords: inhibition glycolysis; glycolysis; hepg2 cells; antioxidant defense ... See more keywords
Activation of the mitogen‐activated protein kinase ERK1/2 signaling pathway suppresses the expression of ChREBPα and β in HepG2 cells
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13208
Abstract: The carbohydrate response element‐binding protein (ChREBP), a glucose‐responsive transcription factor that plays a critical role in the glucose‐mediated induction of genes involved in hepatic glycolysis and lipogenesis, exists as two isoforms: ChREBPα and ChREBPβ. However,… read more here.
Keywords: suppresses expression; expression chrebp; hepg2 cells; hepg2 ... See more keywords
Plantamajoside inhibits the proliferation and epithelial‐to‐mesenchymal transition in hepatocellular carcinoma cells via modulating hypoxia‐inducible factor‐1α‐dependent gene expression
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DOI: 10.1002/cbin.11354
Abstract: As a potential antitumor herbal medicine, plantamajoside (PMS) benefits the treatment of many human malignances. However, the role of PMS in the progression of hepatocellular carcinoma (HCC) and the related molecular mechanisms is still unknown.… read more here.
Keywords: hepatocellular carcinoma; mesenchymal transition; epithelial mesenchymal; hepg2 cells ... See more keywords
The positive feedback loop of furin and TGFβ1 enhances the immune responses of Tregs to hepatocellular carcinoma cells and hepatitis B virus in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11806
Abstract: Regulatory T cells (Tregs) can exert immunosuppressive activity. Furin can regulate Treg functions, hepatitis B virus (HBV) persistent infection, and hepatocellular carcinoma (HCC) development. However, it remains unknown whether furin can regulate the immune responses… read more here.
Keywords: hbv1 hepg2; furin tgf; furin; hepg2 cells ... See more keywords
HepG2 as promising cell-based model for biosynthesis of long-term metabolites - exemplified for metandienone.
Sign Up to like & getrecommendations! Published in 2021 at "Drug testing and analysis"
DOI: 10.1002/dta.3184
Abstract: In order to detect the abuse of substances in sports, the knowledge of their metabolism is of undisputable importance. As in vivo administration of compounds faces ethical problems and might even not be applicable for… read more here.
Keywords: long term; metandienone; cell based; hepg2 cells ... See more keywords
AMPK activator acadesine fails to alleviate isoniazid‐caused mitochondrial instability in HepG2 cells
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DOI: 10.1002/jat.3483
Abstract: Isoniazid (INH) is a first‐line antituberculosis drug that is adversely associated with hepatotoxicity. Recently, impairment of mitochondrial homeostasis involved in this side effect has been noticed. Mitochondrial homeostasis is achieved by the balance between the… read more here.
Keywords: activator acadesine; ampk activator; hepg2 cells; mitochondrial instability ... See more keywords
Naringin abates adverse effects of cadmium‐mediated hepatotoxicity: An experimental study using HepG2 cells
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DOI: 10.1002/jbt.21915
Abstract: This study investigated the protective potential of Naringin (NIN) against cadmium chloride (CdCl2) mediated hepatotoxicity using human hepatocellular carcinoma (HepG2) cells. An optimal concentration of NIN (5 μM) was potent enough to confer cytoprotection against… read more here.
Keywords: naringin abates; mediated hepatotoxicity; study; hepg2 cells ... See more keywords
Apoptosis oxidative damage‐mediated and antiproliferative effect of selenylated imidazo[1,2‐a]pyridines on hepatocellular carcinoma HepG2 cells and in vivo
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DOI: 10.1002/jbt.22663
Abstract: Imidazo[1,2‐a]pyridines (IP) and organoselenium compounds have been widely exploited in medicinal chemistry due to their pharmacological activities. Hepatocellular carcinoma (HCC) has few treatment options, and unfortunately, the prognosis is poor. Thus, the development of novel… read more here.
Keywords: hepatocellular carcinoma; cells vivo; apoptosis oxidative; hepg2 cells ... See more keywords
Fusaric Acid Induces DNA Damage and Post‐Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2) Cells
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DOI: 10.1002/jcb.26037
Abstract: Fusaric acid (FA), a common fungal contaminant of maize, is known to mediate toxicity in plants and animals; however, its mechanism of action is unclear. p53 is a tumor suppressor protein that is activated in… read more here.
Keywords: dna damage; post translational; translational modifications; hepg2 cells ... See more keywords