Protective effects of two novel nitronyl nitroxide radicals on heart failure induced by hypobaric hypoxia.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.05.037
Abstract: AIMS Hypobaric hypoxia (HH), linked to oxidative stress, impairs cardiac function. We synthesized a novel nitronyl nitroxide radical, an HPN derivative (HEPN) and investigated the protective effects of HEPN and HPN against HH-induced heart injury… read more here.
Keywords: nitronyl nitroxide; novel nitronyl; hepn; heart ... See more keywords
Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa634
Abstract: Abstract The type III CRISPR–Cas systems provide immunity against invading nucleic acids through the coordinated transcription-dependent DNA targeting and cyclic adenylate (cAn)-activated RNA degradation. Here, we show that both these pathways contribute to the Streptococcus… read more here.
Keywords: hepn domains; hepn; carf hepn; iii crispr ... See more keywords
Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA
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DOI: 10.1093/nar/gkab513
Abstract: Abstract The rnlAB toxin-antitoxin operon from Escherichia coli functions as an anti-phage defense system. RnlA was identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The activity of… read more here.
Keywords: hepn; required activity; rnla; canonical hepn ... See more keywords