Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48300-3
Abstract: Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is the most abundant protein in normal urine. Defective uromodulin processing is associated with various kidney… read more here.
Keywords: salt; hepsin; uromodulin; thick ascending ... See more keywords
The transmembrane serine protease hepsin suppresses type I interferon induction by cleaving STING
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abb4752
Abstract: The transmembrane protease hepsin reduces antiviral innate immunity in hepatocytes. Viral vulnerability in hepatocytes Chronic viral infections of the liver can lead to organ dysfunction and hepatocellular carcinoma. Hsin et al. found that the transmembrane… read more here.
Keywords: protease hepsin; transmembrane; viral infections; hepsin ... See more keywords
Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1182925
Abstract: Introduction: Hepsin is a type II transmembrane serine protease and its expression has been linked to greater tumorigenicity and worse prognosis in different tumors. Recently, our group demonstrated that high hepsin levels from primary tumor… read more here.
Keywords: cancer; hepsin inhibitor; colorectal cancer; hepsin ... See more keywords
Implication of Hepsin from Primary Tumor in the Prognosis of Colorectal Cancer Patients
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133106
Abstract: Background: Hepsin is a type II transmembrane serine protease whose functions include degradation of the extracellular matrix and activation of factor VII. In many tumors, hepsin dysregulation leads to tumor invasion by proteolysis of pericellular… read more here.
Keywords: hepsin; colorectal cancer; value; intensity ... See more keywords
A High-Affinity 64Cu-Labeled Ligand for PET Imaging of Hepsin: Design, Synthesis, and Characterization
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15091109
Abstract: Hepsin, a cell surface serine protease, is a potential biomarker for the detection of prostate cancer due to its high expression in prostate cancer but not in normal prostate. This study aimed to develop a… read more here.
Keywords: imaging hepsin; prostate cancer; hepsin; radioligand ... See more keywords