The Heptad Repeat C Domain of the Respiratory Syncytial Virus Fusion Protein Plays a Key Role in Membrane Fusion
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DOI: 10.1128/jvi.01323-17
Abstract: ABSTRACT Respiratory syncytial virus (RSV) mediates host cell entry through the fusion (F) protein, which undergoes a conformational change to facilitate the merger of viral and host lipid membrane envelopes. The RSV F protein comprises… read more here.
Keywords: protein; prefusion; membrane fusion; heptad repeat ... See more keywords
Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41
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DOI: 10.1128/mbio.03589-21
Abstract: HIV is a human lentivirus that infects CD4-positive immune cells and, when left untreated, manifests in the fatal disease known as AIDS. Antiretroviral therapy (ART) does not leading to viral clearance, and HIV persists in… read more here.
Keywords: heptad repeat; peptides heptad; hiv; infection ... See more keywords
A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2 and Its Variants of Concern
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DOI: 10.3390/v14030597
Abstract: The prolonged duration of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has resulted in the continuous emergence of variants of concern (VOC, e.g., Omicron) and variants of interest (VOI, e.g., Lambda). These variants have… read more here.
Keywords: fusion; variants concern; heptad repeat; helix ... See more keywords