Naringenin encapsulation in β-CD and in heptakis(2,6-di-O-methyl)-β-CD:NMR, NBO and QTAIM analysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-018-0785-1
Abstract: Using quantum chemistry, we modeled the docking process of flavanone Naringenin guest molecule (Narg) in the host β-Cyclodextrin (β-CD) and also in modified heptakis(2,6-di-O-methyl)-β-CD (DIMEB). The effect of host methylation on the complexation behavior was… read more here.
Keywords: analysis; chemistry; qtaim analysis; nmr nbo ... See more keywords
Compatibility studies with pharmaceutical excipients for aripiprazole–heptakis (2,6-di-O-methyl)-β-cyclodextrin supramolecular adduct
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-020-09901-7
Abstract: Aripiprazole (ARP) is one of the newest antipsychotic drugs, exhibiting very low aqueous solubility and high lipophilicity. Considering the necessity of improvement of ARP physicochemical properties and its biopharmaceutical profile, cyclodextrin complexation of the drug… read more here.
Keywords: compatibility; cyclodextrin; methyl cyclodextrin; spectroscopy ... See more keywords