Clinicopathological and prognostic significance of HER2 status in surgically resected colorectal liver metastases.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of surgical oncology"
DOI: 10.1002/jso.26815
Abstract: BACKGROUND The clinicopathological and prognostic significance of human epidermal growth factor receptor 2 (HER2) status in surgically resected colorectal liver metastases (CRLM) remains uncertain. METHODS HER2 expression was evaluated by immunohistochemical (IHC) in two CRLM… read more here.
Keywords: status; her2 amplification; her2; liver metastases ... See more keywords
HER2 amplification subtype intrahepatic cholangiocarcinoma exhibits high mutation burden and T cell exhaustion microenvironment
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-024-05894-0
Abstract: This study aimed to establish a uniform standard for the interpretation of HER2 gene and protein statuses in intrahepatic cholangiocarcinoma (ICC). We also intended to explore the clinical pathological characteristics, molecular features, RNA expression and… read more here.
Keywords: her2 amplification; microenvironment; intrahepatic cholangiocarcinoma; her2 ... See more keywords
Utility of comprehensive genomic sequencing for detecting HER2-positive colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2017.02.004
Abstract: HER2-targeted therapy is considered effective for KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (CRC). In general, HER2 status is determined by the use of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Comprehensive genomic… read more here.
Keywords: detecting her2; her2 positive; her2 amplification; utility ... See more keywords
RAS/RAF mutations and microsatellite instability status in primary colorectal cancers according to HER2 amplification
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DOI: 10.1038/s41598-024-62096-x
Abstract: HER2 amplification-associated molecular alterations and clinicopathologic features in colorectal cancers (CRCs) have not been well established. In this study, we assessed the prevalence of HER2 amplification and microsatellite instability (MSI) status of 992 patients with… read more here.
Keywords: her2 amplification; crcs; status; amplification ... See more keywords
Automated Quantification of HER2 Amplification Levels Using Deep Learning
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DOI: 10.1109/jbhi.2024.3476554
Abstract: HER2 assessment is necessary for patient selection in anti-HER2 targeted treatment. However, manual assessment of HER2 amplification is time-costly, labor-intensive, highly subjective and error-prone. Challenges in HER2 analysis in fluorescence in situ hybridization (FISH) and… read more here.
Keywords: her2 amplification; her2; tex math; inline formula ... See more keywords
Abstract LB091: Design, characterization and preclinical validation of a combinatorial CAR-based immunotherapy against colorectal cancer with HER2 amplification
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb091
Abstract: Adoptive immunotherapy based on chimeric antigen receptor (CAR)-T cells has led to successful treatment of some hematological malignancies, but it remains extremely challenging for solid tumors, mostly because of “on-target off-tumor” toxicity, as observed in… read more here.
Keywords: immunotherapy; her2 amplification; her2; car ... See more keywords
A Case Report of HER2-Amplification in the Breast Without Histological Abnormality.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of surgical pathology"
DOI: 10.1177/10668969221137514
Abstract: Atypical ductal hyperplasia and low-grade ductal carcinoma in situ (DCIS) are regarded as precursor lesions of estrogen receptor (ER)-positive invasive breast cancer. In HER2-amplified invasive breast cancer, a precursor lesion before DCIS has not yet… read more here.
Keywords: breast; her2; her2 amplification; her2 positive ... See more keywords
Decoding the molecular landscape: HER2 and PD-L1 in advanced gastric cancer
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1567308
Abstract: Introduction Epidermal growth factor receptor 2 (HER2) and programmed cell death ligand 1 (PD-L1) are pivotal therapeutic targets for advanced gastric cancer (GC). Nevertheless, the correlation between them, along with the clinical and genomic characteristics… read more here.
Keywords: advanced gastric; gastric cancer; her2 amplification; amplification ... See more keywords
Long term survival achieved through combination of almonertinib and pyrotinib in EGFR-mutant/HER2-amplified advanced NSCLC patient: a case report and literature review
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1397238
Abstract: Backgroud Human epithelial growth factor receptor 2 (HER2) amplification is an important mechanism of acquired resistance to anti-epidermal growth factor receptor (EGFR) therapy in non-small cell lung cancer (NSCLC) patients. For patients with both EGFR… read more here.
Keywords: her2; almonertinib pyrotinib; nsclc patient; her2 amplification ... See more keywords