Characterisation of HER2‐Driven Morphometric Signature in Breast Cancer and Prediction of Risk of Recurrence
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70852
Abstract: Human epidermal growth factor receptor 2‐positive (HER2‐positive) breast cancer (BC) is a heterogeneous disease. In this study, we hypothesised that the degree of HER2 oncogenic activity, and hence response to anti‐HER2 therapy is translated into… read more here.
Keywords: cancer; breast cancer; characterisation her2; signature ... See more keywords
Personalized therapeutic strategies in HER2-driven gastric cancer
Sign Up to like & getrecommendations! Published in 2021 at "Gastric Cancer"
DOI: 10.1007/s10120-021-01165-w
Abstract: Trastuzumab is the only approved targeted therapy in patients with HER2-amplified metastatic gastric cancer (GC). Regrettably, in clinical practice, only a fraction of them achieves long-term benefit from trastuzumab-based upfront strategy. To advance precision oncology,… read more here.
Keywords: her2 driven; gastric cancer; trastuzumab; strategies her2 ... See more keywords
HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1533
Abstract: Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED1 and HER2… read more here.
Keywords: tumorigenesis; her2 driven; med1; breast tumorigenesis ... See more keywords
Abstract 4034: A potent and highly selective irreversible HER2 inhibitor for treating HER2-driven cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4034
Abstract: HER2 amplification and mutations occur frequently in multiple human cancers, including breast, ovarian, gastric and lung cancers. Despite HER2 being one of the earliest oncogenic drivers discovered, HER2 inhibitors have had limited clinical success compared… read more here.
Keywords: ent; her2; inhibitor; driven cancers ... See more keywords
Abstract LB240: Preclinical evaluation of ABSK112, a selective and CNS-penetrant compound with strong HER2 inhibitory activity for treating HER2-driven solid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-lb240
Abstract: HER2+ cancers, driven by the overexpression or amplification of the HER2 oncogene, are prevalent in various malignancies, including breast, gastric, and lung cancers. These tumors are often associated with a heightened risk of brain metastases.… read more here.
Keywords: selective cns; cns penetrant; her2; her2 driven ... See more keywords
Abstract LB284: VRN101099: A novel treatment option for HER2-driven cancer patients, overcoming T-DXd resistance and brain metastases
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-lb284
Abstract: Many systemic therapeutic options for advanced metastatic HER2-positive breast cancer have been approved, including antibody-based therapies, chemotherapies, and tyrosine kinase inhibitors (TKIs). However, brain metastasis and acquired resistance are still major unmet medical needs for… read more here.
Keywords: vrn101099; cancer; resistance; brain ... See more keywords
Measuring functional HER2-driven signaling status ex vivo to predict response to HER2 therapy: Results from a mouse breast tumor xenograft study.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e23203
Abstract: e23203Background: Clinical trials indicate a weak correlation between HER2 expression levels and HER2 targeted therapy benefit. Other biological factors, such as HER2 signaling activity, may be imp... read more here.
Keywords: driven signaling; her2 driven; measuring functional; functional her2 ... See more keywords