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   Articles with "her2 driven" as a keyword



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Personalized therapeutic strategies in HER2-driven gastric cancer

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recommendations! Published in 2021 at "Gastric Cancer"

DOI: 10.1007/s10120-021-01165-w

Abstract: Trastuzumab is the only approved targeted therapy in patients with HER2-amplified metastatic gastric cancer (GC). Regrettably, in clinical practice, only a fraction of them achieves long-term benefit from trastuzumab-based upfront strategy. To advance precision oncology,… read more here.

Keywords: her2 driven; gastric cancer; trastuzumab; strategies her2 ... See more keywords
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HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1.

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recommendations! Published in 2018 at "Cancer research"

DOI: 10.1158/0008-5472.can-17-1533

Abstract: Studies of the estrogen receptor (ER) coactivator protein Mediator subunit 1 (MED1) have revealed its specific roles in pubertal mammary gland development and potential contributions to breast tumorigenesis, based on coamplification of MED1 and HER2… read more here.

Keywords: tumorigenesis; her2 driven; med1; breast tumorigenesis ... See more keywords
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Abstract 4034: A potent and highly selective irreversible HER2 inhibitor for treating HER2-driven cancers

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-4034

Abstract: HER2 amplification and mutations occur frequently in multiple human cancers, including breast, ovarian, gastric and lung cancers. Despite HER2 being one of the earliest oncogenic drivers discovered, HER2 inhibitors have had limited clinical success compared… read more here.

Keywords: ent; her2; inhibitor; driven cancers ... See more keywords
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Measuring functional HER2-driven signaling status ex vivo to predict response to HER2 therapy: Results from a mouse breast tumor xenograft study.

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recommendations! Published in 2017 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2017.35.15_suppl.e23203

Abstract: e23203Background: Clinical trials indicate a weak correlation between HER2 expression levels and HER2 targeted therapy benefit. Other biological factors, such as HER2 signaling activity, may be imp... read more here.

Keywords: driven signaling; her2 driven; measuring functional; functional her2 ... See more keywords