Assessment of ERBB2/HER2 Status in HER2-Equivocal Breast Cancers by FISH and 2013/2014 ASCO-CAP Guidelines
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2018.6012
Abstract: Importance The 2013/2014 American Society of Clinical Oncology and College of American Pathologists (ASCO-CAP) guidelines for HER2 testing by fluorescence in situ hybridization (FISH) designated an “equivocal” category (average HER2 copies per tumor cell ≥4-6… read more here.
Keywords: her2 equivocal; alternative control; breast; breast cancers ... See more keywords
Rate of reclassification of HER2-equivocal breast cancer cases to HER2-negative per the 2018 ASCO/CAP guidelines and response of HER2-equivocal cases to anti-HER2 therapy
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0241775
Abstract: Purpose The 2018 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) guideline on HER2 testing in breast cancer permits reclassification of cases with HER2-equivocal results by FISH. The impact of such reclassification is unclear.… read more here.
Keywords: her2 equivocal; anti her2; asco cap; her2 negative ... See more keywords
To treat or not to treat: HER2 equivocal is the matter!
Sign Up to like & getrecommendations! Published in 2018 at "Translational cancer research"
DOI: 10.21037/16010
Abstract: With the introduction of the 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines for human epidermal growth factor receptor type 2 (HER2) testing, some authors noticed an increase in equivocal HER2… read more here.
Keywords: her2 equivocal; treat; treat treat; equivocal matter ... See more keywords
Evaluation of ERBB2 mRNA Expression in HER2-Equivocal (2+) Immunohistochemistry Cases
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DOI: 10.3390/cancers15061688
Abstract: Simple Summary HER2-equivocal cases represent around 15% of breast carcinomas, and 20–40% of them are HER2-amplified. The distinction between HER2-amplified and non-amplified cases is of great importance for patient management, and in this study, we… read more here.
Keywords: immunohistochemistry; equivocal cases; her2; mrna expression ... See more keywords