Evolution of low HER2 expression between early and advanced-stage breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of cancer"
DOI: 10.1016/j.ejca.2021.12.022
Abstract: BACKGROUND Low human epidermal growth factor receptor 2 (HER2) expression is emerging as an actionable biomarker for the treatment of breast cancer (BC) with novel anti-HER2 drugs. However, the evolution of this biomarker during the… read more here.
Keywords: her2 expression; expression; breast cancer; her2 low ... See more keywords
In Silico Design and Evaluation of Novel Peptide-Based PET Probe for Noninvasive Imaging of HER2 Expression in Breast Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00760
Abstract: The overexpression of HER2 has been strongly correlated with the pathogenesis and progression of breast cancer. Developing HER2-targeted PET tracers for noninvasive assessment of HER2 expression holds substantial clinical significance for screening patients suitable for… read more here.
Keywords: her2; her2 expression; breast cancer;
Development of a 99mTc-Labeled Single-Domain Antibody for SPECT/CT Assessment of HER2 Expression in Breast Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00569
Abstract: Accurate determination of human epidermal growth factor receptor 2 (HER2) expression is essential for HER2-targeted therapy in patients with cancer. HER2 expression in a complex environment, such as in a heterogeneous tumor, makes the precise… read more here.
Keywords: her2 expression; breast cancer; assessment her2; cancer ... See more keywords
A novel HER2 gene body enhancer contributes to HER2 expression
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/onc.2017.382
Abstract: The transcriptional regulation of the human epidermal growth factor receptor-2 (HER2) contributes to an enhanced HER2 expression in HER2-positive breast cancers with HER2 gene amplification and HER2-low or HER2-negative breast cancers following radiotherapy or endocrine… read more here.
Keywords: her2 gene; her2; gene body; her2 expression ... See more keywords
HER2-low breast cancer is immune-cold: insights into tumor-infiltrating immune cells and implications for immunotherapy.
Sign Up to like & getrecommendations! Published in 2025 at "NPJ breast cancer"
DOI: 10.1038/s41523-025-00867-z
Abstract: This study investigated, for the first time, the association between HER2 expression, immune infiltration inferred by CIBERSORTx, and immunotherapy response in HER2-negative early breast cancer (EBC). Gene expression was analyzed in prospective discovery (n = 104), confirmatory… read more here.
Keywords: her2; her2 low; her2 expression; breast cancer ... See more keywords
Thrombospondin-4 from Cancer-associated Fibroblasts Downregulates ERBB2 Expression in Gastric Cancer Cells.
Sign Up to like & getrecommendations! Published in 2025 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaf064
Abstract: The intra-tumoral heterogeneity of HER2 expression is associated with resistance to anti-HER2 therapy in HER2-positive gastric cancers (GCs). We previously reported that thrombospondin-4 (THBS4) is overexpressed in cancer-associated fibroblasts (CAFs) in the GC microenvironment and… read more here.
Keywords: cancer; her2 expression; erbb2 expression; expression ... See more keywords
Analysis of HER2 expression changes from breast primary to brain metastases and the impact of HER2-low expression on overall survival
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae163
Abstract: Abstract Background There are limited data regarding HER2-low expression dynamics between matched primary tumors and brain metastases (BrMs) in breast cancer. HER2-low expression has emerged as a new therapeutic biomarker for highly active antibody-drug conjugates… read more here.
Keywords: brain; her2 low; her2; her2 expression ... See more keywords
Impact of HER2 on prognosis and benefit from adjuvant chemotherapy in stage II/III gastric cancer patients: a multicenter observational study.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgery"
DOI: 10.1097/js9.0000000000000370
Abstract: BACKGROUND Human epidermal growth factor receptor 2 (HER2) is a well-developed therapeutic target in breast and gastric cancer (GC). However, the impact of HER2 on survival and benefit from fluorouracil-based adjuvant chemotherapy remains unclear in… read more here.
Keywords: her2 expression; stage iii; expression; adjuvant chemotherapy ... See more keywords
Evaluation of fluorine-18-fluorodeoxyglucose PET/computed tomography and human epithelial growth factor receptor 2 expression in treatment-naive patients with lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001530
Abstract: Objective Human epithelial growth factor receptor 2 (HER2) is overexpressed in several types of cancers. The correlation between tumor glucose activity and HER2 expression can vary. This study is a retrospective investigation of fluorine-18-fluorodeoxyglucose PET/computed… read more here.
Keywords: her2 expression; lung adenocarcinoma; pet; expression ... See more keywords
Identification of KRAS mutation and HER2 expression in Indonesian colorectal cancer population: a cross-sectional study
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Medicine and Surgery"
DOI: 10.1097/ms9.0000000000000694
Abstract: Background: In Indonesia, colorectal cancer is the third most common type. In 2008, Indonesia ranked fourth in the Association of Southeast Asian Nations (ASEAN) countries, with an incidence rate of 17.2 per 100 000 population.… read more here.
Keywords: her2 expression; study; colorectal cancer; cancer ... See more keywords
L1CAM and HER2 Expression in Early Endometrioid Uterine Cancer
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Gynecological Pathology"
DOI: 10.1097/pgp.0000000000000338
Abstract: Recently L1CAM was shown to be a promising biomarker for early-stage endometrial carcinoma (EC). As L1CAM expression was found to be related to serous ECs and areas of serous differentiation in endometrioid carcinomas, there is… read more here.
Keywords: l1cam her2; her2 expression; expression; her2 ... See more keywords