Evolution of low HER2 expression between early and advanced-stage breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of cancer"
DOI: 10.1016/j.ejca.2021.12.022
Abstract: BACKGROUND Low human epidermal growth factor receptor 2 (HER2) expression is emerging as an actionable biomarker for the treatment of breast cancer (BC) with novel anti-HER2 drugs. However, the evolution of this biomarker during the… read more here.
Keywords: her2 expression; expression; breast cancer; her2 low ... See more keywords
Development of a 99mTc-Labeled Single-Domain Antibody for SPECT/CT Assessment of HER2 Expression in Breast Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00569
Abstract: Accurate determination of human epidermal growth factor receptor 2 (HER2) expression is essential for HER2-targeted therapy in patients with cancer. HER2 expression in a complex environment, such as in a heterogeneous tumor, makes the precise… read more here.
Keywords: her2 expression; breast cancer; assessment her2; cancer ... See more keywords
A novel HER2 gene body enhancer contributes to HER2 expression
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/onc.2017.382
Abstract: The transcriptional regulation of the human epidermal growth factor receptor-2 (HER2) contributes to an enhanced HER2 expression in HER2-positive breast cancers with HER2 gene amplification and HER2-low or HER2-negative breast cancers following radiotherapy or endocrine… read more here.
Keywords: her2 gene; her2; gene body; her2 expression ... See more keywords
Impact of HER2 on prognosis and benefit from adjuvant chemotherapy in stage II/III gastric cancer patients: a multicenter observational study.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgery"
DOI: 10.1097/js9.0000000000000370
Abstract: BACKGROUND Human epidermal growth factor receptor 2 (HER2) is a well-developed therapeutic target in breast and gastric cancer (GC). However, the impact of HER2 on survival and benefit from fluorouracil-based adjuvant chemotherapy remains unclear in… read more here.
Keywords: her2 expression; stage iii; expression; adjuvant chemotherapy ... See more keywords
Evaluation of fluorine-18-fluorodeoxyglucose PET/computed tomography and human epithelial growth factor receptor 2 expression in treatment-naive patients with lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001530
Abstract: Objective Human epithelial growth factor receptor 2 (HER2) is overexpressed in several types of cancers. The correlation between tumor glucose activity and HER2 expression can vary. This study is a retrospective investigation of fluorine-18-fluorodeoxyglucose PET/computed… read more here.
Keywords: her2 expression; lung adenocarcinoma; pet; expression ... See more keywords
Identification of KRAS mutation and HER2 expression in Indonesian colorectal cancer population: a cross-sectional study
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Medicine and Surgery"
DOI: 10.1097/ms9.0000000000000694
Abstract: Background: In Indonesia, colorectal cancer is the third most common type. In 2008, Indonesia ranked fourth in the Association of Southeast Asian Nations (ASEAN) countries, with an incidence rate of 17.2 per 100 000 population.… read more here.
Keywords: her2 expression; study; colorectal cancer; cancer ... See more keywords
L1CAM and HER2 Expression in Early Endometrioid Uterine Cancer
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Gynecological Pathology"
DOI: 10.1097/pgp.0000000000000338
Abstract: Recently L1CAM was shown to be a promising biomarker for early-stage endometrial carcinoma (EC). As L1CAM expression was found to be related to serous ECs and areas of serous differentiation in endometrioid carcinomas, there is… read more here.
Keywords: l1cam her2; her2 expression; expression; her2 ... See more keywords
Expression and correlation of PD-L1 and HER2 in oesophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Pathology"
DOI: 10.1136/jcp-2022-208665
Abstract: Aims In recent years, patients with programmed cell death-Ligand 1 (PD-L1)-positive oesophageal squamous cell carcinoma (OSCC) have been able to benefit from immunotherapy. However, method for improving the treatment efficacy of PD-L1-positive patients is a… read more here.
Keywords: cell carcinoma; her2 expression; oesophageal squamous; squamous cell ... See more keywords
Abstract P1-02-02: Examination of low Her2 expression in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs21-p1-02-02
Abstract: Introduction: Antibody-drug conjugates (ADC) are designed to effectively deliver cytotoxic agents directly to malignant cells. Trastuzumab deruxtecan (Tdx), an ADC of trastuzumab, an enzyme-cleavable linker, and a cytotoxic topoisomerase I inhibitor, has been shown to… read more here.
Keywords: her2 expression; breast cancer; her2; cancer ... See more keywords
The clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: a meta-analysis of literature
Sign Up to like & getrecommendations! Published in 2017 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-017-1132-5
Abstract: BackgroundHuman epidermal growth factor receptor-2 (HER2) is regarded as an important and promising target in the treatment of HER2-positive breast cancers. However, the correlation of clinicopathological characteristics and prognostic significance of HER2 overexpression in gastric… read more here.
Keywords: cancer patients; her2 expression; gastric cancer; metastasis ... See more keywords
Breast cancer ER, PR, and HER2 expression variance by germline cancer predisposition genes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.10526
Abstract: 10526 Background: The association between breast cancer characteristics and survival with estrogen receptor (ER) and progesterone receptor (PR) expression has been primarily studied via binomial categories, ER-positive and ER-negative. In order to better characterize germline… read more here.
Keywords: expression; cancer predisposition; her2 expression; cancer ... See more keywords