Baicalein suppresses HER2-mediated malignant transformation of HER2-overexpressing ovarian cancer cells by downregulating HER2 gene expression.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23790
Abstract: The upregulation of the HER2 oncogene is associated with a variety of human cancers and is associated with poor prognosis. Baicalein is reported to have anti-tumor activity, but the molecular mechanism of this effect in… read more here.
Keywords: cancer; ovarian cancer; her2; her2 gene ... See more keywords
Development and evaluation of a novel RT-qPCR based test for the quantification of HER2 gene expression in breast cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.12.027
Abstract: Accurate measurement of Human epidermal growth factor receptor (HER2) gene expression is central for breast or stomach cancer therapy orientation and prognosis. The current standards testing methods for HER2 expression are immunohistochemistry (IHC) and fluorescence… read more here.
Keywords: her2 gene; expression; quantification; gene ... See more keywords
A novel HER2 gene body enhancer contributes to HER2 expression
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/onc.2017.382
Abstract: The transcriptional regulation of the human epidermal growth factor receptor-2 (HER2) contributes to an enhanced HER2 expression in HER2-positive breast cancers with HER2 gene amplification and HER2-low or HER2-negative breast cancers following radiotherapy or endocrine… read more here.
Keywords: her2 gene; her2; gene body; her2 expression ... See more keywords
HER2 Gene Protein Assay: A Robust Tool for Evaluating HER2 Status and Intratumoral Heterogeneity in Endometrial Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqac179
Abstract: OBJECTIVES Human epidermal growth factor receptor 2 (HER2) status in endometrial cancer is usually determined by immunohistochemistry and/or in situ hybridization. We employed a novel HER2 gene protein assay (GPA) to simultaneously assesses HER2 gene… read more here.
Keywords: her2 status; her2 gene; her2; endometrial cancers ... See more keywords
The expression of HER2-gene polymorphisms -1985G>T and P1170A C>G and their association with the risk of development of lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz260.077
Abstract: Abstract Background HER2-gene mutations are considered to be an important prognostic factor in patients with lung cancer. The aim of our study was to assess the frequency and significance of HER2-gene single nucleotide polymorphisms -1985G>T… read more here.
Keywords: lung adenocarcinoma; 1985g p1170a; gene; her2 gene ... See more keywords
The Influence of Heavy Metals on Gastric Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/6425133
Abstract: Objectives This study aimed to observe the relationship among heavy metals concentration, microsatellite instability (MSI), and human epidermal growth factor receptor type 2 (HER2) gene amplification in gastric cancer (GC) patients. Methods The concentrations of… read more here.
Keywords: her2 gene; heavy metals; amplification; msi ... See more keywords
A decision tree-based prediction model for fluorescence in situ hybridization HER2 gene status in HER2 immunohistochemistry-2+ breast cancers: a 2538-case multicenter study on consecutive surgical specimens
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer"
DOI: 10.7150/jca.25586
Abstract: Objective: To investigate the proportion of HER2 gene amplifications and the association between the HER2-IHC-staining pattern and gene status in IHC-2+ breast cancers according to 2013 American Society of Clinical Oncology (ASCO)/College of American Pathologists… read more here.
Keywords: staining pattern; gene status; breast; her2 gene ... See more keywords