A common MET polymorphism harnesses HER2 signaling to drive aggressive squamous cell carcinoma
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DOI: 10.1038/s41467-020-15318-5
Abstract: c-MET receptors are activated in cancers through genomic events like tyrosine kinase domain mutations, juxtamembrane splicing mutation and amplified copy numbers, which can be inhibited by c-MET small molecule inhibitors. Here, we discover that the… read more here.
Keywords: polymorphism; squamous cell; her2 signaling; her2 ... See more keywords
Activated TAZ induces liver cancer in collaboration with EGFR/HER2 signaling pathways
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DOI: 10.1186/s12885-022-09516-1
Abstract: Background Liver cancer is a major global health concern due to the steady increases in its incidence and mortality. Transcription factors, yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1, also known as… read more here.
Keywords: egfr her2; cancer; signaling pathways; taz ... See more keywords