Long-term follow-up assessment of cardiac safety in SAFE-HEaRt, a clinical trial evaluating the use of HER2-targeted therapies in patients with breast cancer and compromised heart function
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DOI: 10.1007/s10549-020-06053-y
Abstract: Purpose HER2-targeted therapies are associated with cardiotoxicity which is usually asymptomatic and reversible. We report the updated cardiac safety assessment of patients with compromised heart function receiving HER2-targeted therapy for breast cancer, enrolled in the… read more here.
Keywords: heart; targeted therapies; her2 targeted; breast cancer ... See more keywords
Safety and pharmacokinetics of MM-302, a HER2-targeted antibody–liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study
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DOI: 10.1038/s41416-018-0235-2
Abstract: BackgroundThis phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody–liposomal doxorubicin conjugate, in HER2-positive locally advanced/metastatic breast cancer.MethodsPatients were enrolled in four cohorts: MM-302 monotherapy (8, 16, 30, 40, and 50 mg/m2 every 4… read more here.
Keywords: phase; dose escalation; her2 targeted; cancer ... See more keywords
HER2-targeted therapies — a role beyond breast cancer
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DOI: 10.1038/s41571-019-0268-3
Abstract: HER2 is an established therapeutic target in a large subset of women with breast cancer; a variety of agents including trastuzumab, pertuzumab, lapatinib, neratinib and trastuzumab emtansine (T-DM1) have been approved for the treatment of… read more here.
Keywords: breast cancer; her2 targeted; cancer; her2 ... See more keywords
Targeted agents for HER2-positive breast cancer in older adults: current and future perspectives
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DOI: 10.1080/13543784.2018.1520838
Abstract: ABSTRACT Introduction: One-third of breast cancer (BC) cases worldwide occur in women aged 65 years and older, with 10 to 15% overexpressing the human epidermal growth factor receptor 2 (HER2). Although several HER2-targeted therapies have… read more here.
Keywords: older adults; targeted therapies; her2 targeted; breast cancer ... See more keywords
Experimental HER2- targeted therapies for biliary tract cancer
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DOI: 10.1080/13543784.2021.1854724
Abstract: ABSTRACT Introduction: Biliary tract cancers (BTCs) constitute a heterogeneous group of poor-prognosis solid tumors with limited treatment options. In the last decade, global efforts have tried to identify therapeutic targets by genomic profiling of BTC,… read more here.
Keywords: biliary tract; her2 targeted; cancer; her2 ... See more keywords
Efficacy and safety of a combination of HER2-targeted agents as first-line treatment for metastatic HER2-positive breast cancer: a network meta-analysis
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DOI: 10.1080/14740338.2018.1394454
Abstract: ABSTRACT Background: Using network meta-analysis, we assessed the efficacy and safety of a combination regimen of HER2-targeted agents as first-line treatment for metastatic HER2-positive breast cancer. Methods: We searched the Medline, Embase, and Cochrane Library… read more here.
Keywords: network meta; first line; line treatment; her2 targeted ... See more keywords
Cardiotoxicity of HER2-targeted therapies.
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DOI: 10.1097/hco.0000000000000637
Abstract: PURPOSE OF REVIEW Cardiotoxicity is a well recognized adverse effect of human epidermal growth factor receptor 2 (HER2)-targeted therapies. The goal of this review is to highlight recent studies that have advanced our knowledge of… read more here.
Keywords: risk; her2 targeted; targeted therapies; cardiotoxicity her2 ... See more keywords
Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer
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DOI: 10.1158/1078-0432.ccr-18-3389
Abstract: Purpose: ERBB2 (HER2) amplification is an emerging biomarker in colon cancer, conferring sensitivity to combination anti-HER2 therapy. Measurement of HER2 copy number is typically performed using surgical specimens, but cell-free circulating tumor DNA (ctDNA) analysis… read more here.
Keywords: response; pcn; copy number; her2 targeted ... See more keywords
Abstract P1-18-01: Risk of recurrence and death in patients with early HER2-positive breast cancer who achieve a pathological complete response (pCR) after different types of HER2-targeted therapy: A retrospective exploratory analysis
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DOI: 10.1158/1538-7445.sabcs19-p1-18-01
Abstract: Background: The current standard of care for patients achieving a pCR after HER2-targeted therapy plus chemotherapy in the neoadjuvant setting is to continue HER2-targeted therapy in the adjuvant setting. The aim of this exploratory data… read more here.
Keywords: therapy; analysis; targeted therapy; breast cancer ... See more keywords
Abstract P4-10-13: Validation of neural network approach for the prediction of HER2-targeted neoadjuvant chemotherapy response from pretreatment MRI: A multi-site study
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DOI: 10.1158/1538-7445.sabcs19-p4-10-13
Abstract: Background: Although the advent of targeted therapy has substantially improved outcomes for HER2+ breast cancer patients, many will still fail to achieve pathological complete response (pCR) following neoadjuvant chemotherapy (NAC). In order to reduce overtreatment… read more here.
Keywords: neural network; response; her2 targeted; cohort ... See more keywords
Abstract PS9-54: Healthcare costs for metastatic breast cancer patients treated with human epidermal growth factor receptor 2 targeted agents
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DOI: 10.1158/1538-7445.sabcs20-ps9-54
Abstract: Background: Human Epidermal Growth Factor Receptor 2 positive (HER2+) breast cancer (BC) represents approximately 15% of early stage BC cases and is associated with a more aggressive clinical phenotype and poor prognosis with respect to… read more here.
Keywords: her2 targeted; year; cancer; targeted therapy ... See more keywords